Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | ITK | Q08881 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6702887 | 0.91 | MAPK1 (0.49) | TP53TDP1IDO1MAPK1MAPK3 | |
| SCHEMBL6699272 | 0.91 | TP53 (0.51) | TP53TDP1MAPK10MAPK8IDO1 | |
| SCHEMBL6703136 | 0.90 | TP53 (0.47) | TP53TDP1IDO1SMN1; SMN2MAPK1 | |
| SCHEMBL6694919 | 0.88 | TP53 (0.53) | TP53TDP1MAPK1MAPK3NPC1 | |
| SCHEMBL6664702 | 0.85 | TP53 (0.54) | TP53TDP1IDO1SMN1; SMN2MAPT | |
| SCHEMBL6664832 | 0.84 | TP53 (0.54) | TP53TDP1MAPK1MAPTHPGD | |
| SCHEMBL6702873 | 0.84 | TP53 (0.47) | TP53TDP1MAPK10MAPK8IDO1 | |
| SCHEMBL6705339 | 0.84 | TP53 (0.44) | TP53TDP1SMN1; SMN2MAPK1HPGD | |
| SCHEMBL6700631 | 0.83 | ALDH1A1 (0.46) | TP53TDP1SMN1; SMN2MAPK1MAPK3 | |
| SCHEMBL6703840 | 0.82 | TP53 (0.53) | TP53TDP1MAPK10MAPK8MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1441725-A1 | BENZIMIDAZOLES AND ANALOGUES AND THEIR USE AS PROTEIN KINASES INHIBITORS | Aventis Pharmaceuticals Inc. (US) | 2004-08-04 | — | — | EP | claimed |
| WO-2003035065-A1 | BENZIMIDAZOLES AND ANALOGUES AND THEIR USE AS PROTEIN KINASES INHIBITORS | AVENTIS PHARMACEUTICALS INC (US) | 2003-05-01 | — | — | WO | claimed |