Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | CASP6 | P55212 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.43 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6699272 | 0.89 | TP53 (0.51) | TP53LMNAPPARGMAPK1MAPK3 | |
| SCHEMBL6694919 | 0.85 | TP53 (0.53) | TP53LMNAPPARGMAPK1MAPK3 | |
| SCHEMBL6664832 | 0.85 | TP53 (0.54) | TP53LMNAMAPK1MAPTTDP1 | |
| SCHEMBL6702873 | 0.83 | TP53 (0.47) | TP53LMNAPPARGMAPK1EPHX2 | |
| SCHEMBL6702887 | 0.82 | MAPK1 (0.49) | TP53LMNAPPARGMAPK1MAPK3 | |
| SCHEMBL6694288 | 0.82 | TP53 (0.51) | TP53MAPK1MAPK3MAPTMAPK8 | |
| SCHEMBL6703136 | 0.81 | TP53 (0.47) | TP53LMNAPPARGMAPK1MAPK3 | |
| SCHEMBL6664702 | 0.81 | TP53 (0.54) | TP53LMNAPPARGMAPTTDP1 | |
| SCHEMBL6705339 | 0.79 | TP53 (0.44) | TP53LMNAMAPK1TDP1 | |
| SCHEMBL6700631 | 0.78 | ALDH1A1 (0.46) | TP53LMNAPPARGMAPK1MAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1441725-A1 | BENZIMIDAZOLES AND ANALOGUES AND THEIR USE AS PROTEIN KINASES INHIBITORS | Aventis Pharmaceuticals Inc. (US) | 2004-08-04 | — | — | EP | claimed |
| WO-2003035065-A1 | BENZIMIDAZOLES AND ANALOGUES AND THEIR USE AS PROTEIN KINASES INHIBITORS | AVENTIS PHARMACEUTICALS INC (US) | 2003-05-01 | — | — | WO | claimed |