Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.44 |
| ▸ | PPARG | P37231 | 2/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6702873 | 0.91 | TP53 (0.47) | TP53LMNAEPHX2PPARGTDP1 | |
| SCHEMBL6664832 | 0.89 | TP53 (0.54) | TP53LMNATDP1HPGDMAPK1 | |
| SCHEMBL6703136 | 0.89 | TP53 (0.47) | TP53LMNAEPHX2PPARGTDP1 | |
| SCHEMBL6702887 | 0.88 | MAPK1 (0.49) | TP53LMNAPPARGTDP1HPGD | |
| SCHEMBL6694288 | 0.88 | TP53 (0.51) | TP53TDP1HPGDMAPK1NPC1 | |
| SCHEMBL6703840 | 0.85 | TP53 (0.53) | TP53LMNAEPHX2PPARGTDP1 | |
| SCHEMBL6705339 | 0.85 | TP53 (0.44) | TP53LMNAROCK2TDP1HPGD | |
| SCHEMBL6699272 | 0.84 | TP53 (0.51) | TP53LMNAPPARGTDP1MAPK1 | |
| SCHEMBL6664702 | 0.83 | TP53 (0.54) | TP53LMNAPPARGTDP1HPGD | |
| SCHEMBL6700631 | 0.80 | ALDH1A1 (0.46) | TP53LMNAPPARGROCK2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1441725-A1 | BENZIMIDAZOLES AND ANALOGUES AND THEIR USE AS PROTEIN KINASES INHIBITORS | Aventis Pharmaceuticals Inc. (US) | 2004-08-04 | — | — | EP | claimed |
| WO-2003035065-A1 | BENZIMIDAZOLES AND ANALOGUES AND THEIR USE AS PROTEIN KINASES INHIBITORS | AVENTIS PHARMACEUTICALS INC (US) | 2003-05-01 | — | — | WO | claimed |