Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 8/20 | 0.40 |
| ▸ | CNR2 | P34972 | 8/20 | 0.40 |
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6688988 | 0.99 | ALDH1A1 (0.39) | ALDH1A1KMT2AP2RX7MAPK8CNR1 | |
| SCHEMBL5207833 | 0.81 | HDAC1 (0.51) | KMT2AMAPK8KDM4E | |
| SCHEMBL6689321 | 0.80 | HDAC1 (0.42) | ALDH1A1KMT2AKDM4E | |
| SCHEMBL6689259 | 0.80 | HDAC1 (0.40) | ALDH1A1KMT2AP2RX7KDM4E | |
| SCHEMBL6693538 | 0.80 | HDAC1 (0.42) | ALDH1A1KMT2AP2RX7KDM4EHPGD | |
| SCHEMBL6774729 | 0.80 | HDAC1 (0.45) | ALDH1A1KMT2AP2RX7KDM4E | |
| SCHEMBL15069289 | 0.79 | PARP1 (0.43) | ALDH1A1KMT2APARP1KDM4EHPGD | |
| SCHEMBL6693115 | 0.79 | FABP3 (0.45) | ALDH1A1KMT2AKDM4E | |
| SCHEMBL6691809 | 0.79 | HDAC1 (0.44) | P2RX7KDM4E | |
| SCHEMBL6694051 | 0.79 | HDAC1 (0.44) | ALDH1A1KMT2AKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0950657-B1 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitors | LILLY CO ELI (US) | 2004-07-14 | — | — | EP | disclosed |
| EP-0952149-B1 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | LILLY CO ELI (US) | 2004-06-09 | — | — | EP | disclosed |
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |
| EP-0950657-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitors | ELI LILLY AND COMPANY (US) | 1999-10-20 | — | — | EP | disclosed |