Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.61 |
| ▸ | NR4A2 | P43354 | 5/20 | 0.60 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.55 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.53 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | PTGES | O14684 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.49 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.49 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.49 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.49 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29447425 | 1.00 | MAOB (0.61) | MAOBNR4A2SMPD1SRD5A2KMT2A | |
| SCHEMBL669531 | 1.00 | MAOB (0.61) | MAOBNR4A2SMPD1SRD5A2KMT2A | |
| SCHEMBL16740956 | 0.92 | MAOB (0.53) | MAOBNR4A2SMPD1SRD5A2KMT2A | |
| SCHEMBL16740955 | 0.92 | MAOB (0.53) | MAOBNR4A2SMPD1SRD5A2KMT2A | |
| SCHEMBL7117584 | 0.85 | MAOB (0.59) | MAOBNR4A2SMPD1SRD5A2KMT2A | |
| SCHEMBL7117578 | 0.85 | MAOB (0.59) | MAOBNR4A2SMPD1SRD5A2KMT2A | |
| Hydrochloric Acid SCHEMBL7165699 | 0.84 | MAOB (0.57) | MAOBNR4A2SMPD1SRD5A2KMT2A | |
| Hydrochloric Acid SCHEMBL7164131 | 0.84 | MAOB (0.57) | MAOBNR4A2SMPD1SRD5A2KMT2A | |
| SCHEMBL20364678 | 0.84 | MAOB (0.71) | MAOBNR4A2SMPD1SRD5A2KMT2A | |
| SCHEMBL16740948 | 0.84 | MAOB (0.53) | MAOBNR4A2SMPD1SRD5A2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12172944-B2 | Process for the preparation of tapentadol and analogs thereof | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2024-12-24 | — | — | US | disclosed |
| US-20220177413-A1 | PROCESS FOR THE PREPARATION OF TAPENTADOL AND ANALOGS THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2022-06-09 | — | — | US | disclosed |
| EP-3947342-A1 | PROCESS FOR THE PREPARATION OF TAPENTADOL AND ANALOGS THEREOF | Council of Scientific and Industrial Research (IN) | 2022-02-09 | — | — | EP | disclosed |
| WO-2020194326-A1 | PROCESS FOR THE PREPARATION OF TAPENTADOL AND ANALOGS THEREOF | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2020-10-01 | — | — | WO | disclosed |
| US-9663456-B2 | Intermediate of tapentadol | SUN PHARMA ADVANCED RESEARCH COMPANY (IN) | 2017-05-30 | — | — | US | disclosed |
| US-20160264521-A1 | NOVEL INTERMEDIATE OF TAPENTADOL | SUN PHARMA ADVANCED RESEARCH COMPANY (IN) | 2016-09-15 | — | — | US | disclosed |
| EP-3063125-A1 | NOVEL INTERMEDIATE OF TAPENTADOL | Sun Pharma Advanced Research Company (IN) | 2016-09-07 | — | — | EP | disclosed |
| EP-2606030-B1 | PROCESS FOR THE PREPARATION OF TAPENTADOL | INDOCO REMEDIES LTD (IN) | 2016-05-18 | — | — | EP | disclosed |
| WO-2015075744-A1 | NOVEL INTERMEDIATE OF TAPENTADOL | SUN PHARMA ADVANCED RESEARCH COMPANY (IN) | 2015-05-28 | — | — | WO | disclosed |
| US-8853456-B2 | Process for the preparation of tapentadol | INDOCO REMEDIES LIMITED (US) | 2014-10-07 | — | — | US | disclosed |
| US-8263809-B2 | that is, tapentadol or tapentadol hydrochloride; novel intermediates | GRUENENTHAL GMBH (DE) | 2012-09-11 | — | — | US | disclosed |
| WO-2012023147-A1 | PROCESS FOR THE PREPARATION OF TAPENTADOL | INDOCO REMEDIES LIMITED (IN) | 2012-02-23 | — | — | WO | disclosed |
| EP-2049464-B1 | PREPARATION OF 3-[(1R,2R)-3-(DIMETHYLAMINO)-1ETHYL-2-METHYLPROPYL]PHENOL | GRUENENTHAL GMBH (DE) | 2011-07-06 | — | — | EP | disclosed |
| EP-2049464-B1 | PREPARATION OF 3-[(1R,2R)-3-(DIMETHYLAMINO)-1ETHYL-2-METHYLPROPYL]PHENOL | GRUENENTHAL GMBH (DE) | 2011-07-06 | — | — | EP | disclosed |
| US-20090326271-A1 | Preparation of 3-[(1R,2R)-3-(Dimethylamino)-1Ethyl-2-Methylpropyl]phenol | GRUENENTHAL GMBH (DE) | 2009-12-31 | — | — | US | disclosed |
| US-20090326271-A1 | Preparation of 3-[(1R,2R)-3-(Dimethylamino)-1Ethyl-2-Methylpropyl]phenol | GRUENENTHAL GMBH (DE) | 2009-12-31 | — | — | US | disclosed |
| US-20090326271-A1 | Preparation of 3-[(1R,2R)-3-(Dimethylamino)-1Ethyl-2-Methylpropyl]phenol | GRUENENTHAL GMBH (DE) | 2009-12-31 | — | — | US | disclosed |
| EP-2049464-A1 | PREPARATION OF 3-Ý(1R,2R)-3-(DIMETHYLAMINO)-1ETHYL-2-METHYLPROPYL¨PHENOL | Grünenthal GmbH (DE) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008012046-A1 | PREPARATION OF 3-[(1R,2R)-3-(DIMETHYLAMINO)-1ETHYL-2-METHYLPROPYL]PHENOL | Grünenthal GmbH (DE) | 2008-01-31 | — | — | WO | disclosed |
| WO-2008012046-A1 | PREPARATION OF 3-[(1R,2R)-3-(DIMETHYLAMINO)-1ETHYL-2-METHYLPROPYL]PHENOL | Grünenthal GmbH (DE) | 2008-01-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090326271-A1 | Preparation of 3-[(1R,2R)-3-(Dimethylamino)-1Ethyl-2-Methylpropyl]phenol | CYP1A1, PAH, CYP2E1 | MAOB 403/4885NR4A2 843/4885SMPD1 3195/4885 |
| US-12172944-B2 | Process for the preparation of tapentadol and analogs thereof | CYP1A1, CYP1B1, OPRL1 | MAOB 140/4885NR4A2 1452/4885SMPD1 2028/4885 |
| US-20160264521-A1 | NOVEL INTERMEDIATE OF TAPENTADOL | OPRD1, OPRK1, OPRM1 | MAOB 1143/4885NR4A2 1368/4885SMPD1 2627/4885 |
| US-20220177413-A1 | PROCESS FOR THE PREPARATION OF TAPENTADOL AND ANALOGS THEREOF | CYP1A1, CYP1B1, OPRL1 | MAOB 140/4885NR4A2 1452/4885SMPD1 2028/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.