Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 6/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | RAD52 | P43351 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | SLC9A3 | P48764 | 3/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6700490 | 0.90 | KMT2A (0.70) | MPOKMT2ARAD52POLBMEN1 | |
| SCHEMBL6694553 | 0.82 | KMT2A (0.81) | MPOKMT2ARAD52POLBMEN1 | |
| SCHEMBL6700083 | 0.78 | MPO (0.57) | MPOKMT2ARAD52POLBMEN1 | |
| SCHEMBL6693265 | 0.78 | KMT2A (0.73) | MPOKMT2ARAD52POLBMEN1 | |
| SCHEMBL6695583 | 0.76 | APEX1 (0.46) | POLBMAPTAPEX1ADORA2AACHE | |
| SCHEMBL6695998 | 0.76 | KMT2A (0.70) | MPOKMT2ARAD52POLBMEN1 | |
| SCHEMBL6698132 | 0.76 | RAD52 (0.70) | MPOKMT2ARAD52POLBMEN1 | |
| SCHEMBL27571649 | 0.74 | POLB (0.67) | MPOKMT2ARAD52POLBMEN1 | |
| SCHEMBL2124097 | 0.73 | APEX1 (0.52) | POLBAPEX1ACHE | |
| SCHEMBL6695760 | 0.73 | KMT2A (0.97) | MPOKMT2ARAD52POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040224965-A1 | 2-Guanidino-4-arylchinazolines as nhe-3 inhibitors | MERCK PATENT GMBH (DE) | 2004-11-11 | — | — | US | claimed |
| CN-1422260-A | 2-guanidino-4-arylchinazolines as NHE-3 inhibitors | MERCK PATENT GMBH (DE) | 2003-06-04 | — | — | CN | claimed |
| US-20040224965-A1 | 2-Guanidino-4-arylchinazolines as nhe-3 inhibitors | MERCK PATENT GMBH (DE) | 2004-11-11 | — | — | US | disclosed |
| CN-1422260-A | 2-guanidino-4-arylchinazolines as NHE-3 inhibitors | MERCK PATENT GMBH (DE) | 2003-06-04 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040224965-A1 | 2-Guanidino-4-arylchinazolines as nhe-3 inhibitors | NHERF1, SLC9A3, SLC9A1 | MPO 1003/4885KMT2A 3326/4885RAD52 4856/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.