Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 1/20 | 0.61 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.61 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.61 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.60 |
| ▸ | RAB9A | P51151 | 4/20 | 0.60 |
| ▸ | HPGD | P15428 | 4/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.49 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL669563 | 1.00 | MAPK13 (0.61) | MAPK13MAPK12MAPK11MAPK14ALDH1A1 | |
| SCHEMBL1615179 | 0.85 | ALDH1A1 (0.65) | MAPK13MAPK12MAPK11MAPK14ALDH1A1 | |
| SCHEMBL11453059 | 0.85 | PTGS1 (0.55) | MAPK13MAPK12MAPK11MAPK14ALDH1A1 | |
| SCHEMBL11453058 | 0.85 | PTGS1 (0.55) | MAPK13MAPK12MAPK11MAPK14ALDH1A1 | |
| SCHEMBL33928 | 0.85 | TDP1 (0.56) | ALDH1A1HPGDSMN1; SMN2L3MBTL1MEN1 | |
| SCHEMBL1531678 | 0.85 | TDP1 (0.56) | ALDH1A1HPGDSMN1; SMN2L3MBTL1MEN1 | |
| SCHEMBL1330911 | 0.85 | TDP1 (0.56) | ALDH1A1HPGDSMN1; SMN2L3MBTL1MEN1 | |
| SCHEMBL1331551 | 0.85 | TDP1 (0.56) | ALDH1A1HPGDSMN1; SMN2L3MBTL1MEN1 | |
| SCHEMBL33927 | 0.85 | TDP1 (0.56) | ALDH1A1HPGDSMN1; SMN2L3MBTL1MEN1 | |
| Water SCHEMBL11454954 | 0.83 | PTGS1 (0.54) | MAPK13MAPK12MAPK11MAPK14ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103261167-B | 6 of replacement, 6-condenses nitrogen-containing heterocycle compound and uses thereof | HOFFMAN-LA ROCHE LTD. (CH) | 2016-05-04 | — | — | CN | disclosed |
| CN-104302177-A | Carrier for improved drug delivery | EXTEND BIOSCIENCES INC | 2015-01-21 | — | — | CN | disclosed |
| EP-2605789-A2 | MODIFIED RELAXIN POLYPEPTIDES AND THEIR USES | Ambrx, Inc. (US) | 2013-06-26 | — | — | EP | disclosed |
| CN-102821775-A | Pharmaceutical compositions of growth hormone secretagogue receptor ligands | IPSEN PHARMA SAS | 2012-12-12 | — | — | CN | disclosed |
| WO-2012024452-A2 | MODIFIED RELAXIN POLYPEPTIDES AND THEIR USES | AMBRX, INC. (US) | 2012-02-23 | — | — | WO | disclosed |
| EP-2337795-A2 | MHC MULTIMERS IN CANCER VACCINES AND IMMUNE MONITORING | Dako Denmark A/S (DK) | 2011-06-29 | — | — | EP | disclosed |
| CN-102076214-A | Gastrin releasing peptide compounds | BRACCO IMAGING SPA | 2011-05-25 | — | — | CN | disclosed |
| EP-2281580-A2 | Labeled gastrin releasing peptides (GRP) | Bracco Imaging S.p.A (IT) | 2011-02-09 | — | — | EP | disclosed |
| WO-2010037395-A2 | MHC MULTIMERS IN CANCER VACCINES AND IMMUNE MONITORING | DAKO DENMARK A/S (DK) | 2010-04-08 | — | — | WO | disclosed |
| US-20090221483-A1 | Antimicrobial Cathelicidin Peptides | KANSAS STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2009-09-03 | — | — | US | disclosed |
| US-6559141-B2 | Inhibit beta-amyloid peptide release and/or synthesis, use in treating Alzheimer's disease; for example, 5-(N'-(phenylacetyl)-L-alpha-(2-thienyl)glycinyl)-amino-7-methyl-5,7-dihydro-6H-dibenz(b, d)azepin-6-one | ATHENA NEUROSCIENCES, INC. | 2003-05-06 | — | — | US | disclosed |
| US-6544978-B2 | Treating Alzheimer's disease both prophylactically and therapeutically | ATHENA NEUROSCIENCES, INC. | 2003-04-08 | — | — | US | disclosed |
| US-6506782-B1 | Compounds which inhibit beta -amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits beta | ATHENA NEUROSCIENCES, INC. | 2003-01-14 | — | — | US | disclosed |
| WO-2002100885-A2 | A PENTA- OR TETRAPEPTIDE BINDING TO SOMATOSTATIN RECEPTORS AND THE USE OF THE SAME | NOVASPIN BIOTECH GMBH (DE) | 2002-12-19 | — | — | WO | disclosed |
| CN-1283507-A | Method of treating skin pigmentation | JOHNSON & JOHNSON CONSUMER (US) | 2001-02-14 | — | — | CN | disclosed |
| EP-0730605-A1 | SUBSTITUTED DI- AND TRIPEPTIDE INHIBITORS OF PROTEIN:FARNESYL TRANSFERASE | WARNER-LAMBERT COMPANY (US) | 1996-09-11 | — | — | EP | disclosed |
| EP-0725790-A1 | SUBSTITUTED TETRA- AND PENTAPEPTIDE INHIBITORS OF PROTEIN:FARNESYL TRANSFERASE | PARKE DAVIS & COMPANY (US) | 1996-08-14 | — | — | EP | disclosed |
| WO-1996017861-A1 | SUBSTITUTED TETRA- AND PENTAPEPTIDE INHIBITORS OF PROTEIN:FARNESYL TRANSFERASE | WARNER-LAMBERT COMPANY (US) | 1996-06-13 | — | — | WO | disclosed |
| WO-1995012612-A1 | SUBSTITUTED DI- AND TRIPEPTIDE INHIBITORS OF PROTEIN:FARNESYL TRANSFERASE | WARNER-LAMBERT COMPANY (US) | 1995-05-11 | — | — | WO | disclosed |
| WO-1995011917-A1 | SUBSTITUTED TETRA- AND PENTAPEPTIDE INHIBITORS OF PROTEIN:FARNESYL TRANSFERASE | PARKE, DAVIS & COMPANY (US) | 1995-05-04 | — | — | WO | disclosed |