Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 6/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.52 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.52 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.52 |
| ▸ | GCGR | P47871 | 1/20 | 0.52 |
| ▸ | USP1 | O94782 | 1/20 | 0.47 |
| ▸ | USP19 | O94966 | 1/20 | 0.47 |
| ▸ | UCHL3 | P15374 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CCR6 | P51684 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7503500 | 1.00 | MAPK14 (0.52) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL1387188 | 0.90 | MAPK14 (0.65) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL16993493 | 0.90 | MAPK14 (0.65) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL9113400 | 0.86 | MAPK14 (0.61) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL8549078 | 0.81 | PTGS2 (0.40) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL1387186 | 0.81 | MAPK14 (0.71) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL8553156 | 0.80 | PTGS2 (0.68) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL7504194 | 0.80 | PTGS2 (0.68) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL213979 | 0.80 | PTGS2 (0.68) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL7503429 | 0.79 | MAPK14 (0.81) | MAPK14MAPK13MAPK12MAPK11GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004096206-A2 | THERAPEUTIC COMBINATION OF A COX-2 INHIBITOR AND A TACE INHIBITOR | PHARMACIA CORPORATION (US) | 2004-11-11 | — | — | WO | disclosed |