Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 6/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CCR6 | P51684 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.36 |
| ▸ | GCGR | P47871 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6695860 | 0.81 | MAPK14 (0.52) | PTGS2PTGS1MAPK14CYP1A2POLB | |
| SCHEMBL7503500 | 0.81 | MAPK14 (0.52) | PTGS2PTGS1MAPK14CYP1A2POLB | |
| SCHEMBL7503544 | 0.81 | PTGS2 (0.64) | PTGS2PTGS1 | |
| SCHEMBL9024375 | 0.79 | PTGS2 (0.65) | PTGS2PTGS1CYP1A2POLBHSP90AA1 | |
| SCHEMBL7499074 | 0.79 | PTGS2 (0.62) | PTGS2PTGS1PTGDR2 | |
| SCHEMBL8295663 | 0.76 | KMT2A (0.39) | PTGS2PTGS1CYP1A2POLBHSP90AA1 | |
| SCHEMBL1387188 | 0.74 | MAPK14 (0.65) | PTGS2PTGS1MAPK14MAPK11MAPK13 | |
| SCHEMBL16993493 | 0.74 | MAPK14 (0.65) | PTGS2PTGS1MAPK14MAPK11MAPK13 | |
| SCHEMBL9025437 | 0.73 | PTGS2 (0.45) | PTGS2PTGS1MAPK14CYP3A4HPGD | |
| SCHEMBL8551444 | 0.71 | PTGS2 (0.39) | PTGS2PTGS1MAPK14MAPK11MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825989-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1998-03-04 | — | — | EP | disclosed |