Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 10/20 | 0.45 |
| ▸ | SLC6A2 known ✓ | P23975 | 9/20 | 0.45 |
| ▸ | SLC6A3 known ✓ | Q01959 | 6/20 | 0.45 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.35 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.35 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.42 |
| ▸ | NOS2 | P35228 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL6696144 | 1.00 | SLC6A4 (0.45) | SLC6A4SLC6A2SLC6A3S1PR3NOS2 | |
| Fumaric Acid SCHEMBL5381484 | 0.95 | SLC6A2 (0.43) | SLC6A4SLC6A2SLC6A3S1PR3NOS2 | |
| Fumaric Acid SCHEMBL5381494 | 0.95 | SLC6A2 (0.43) | SLC6A4SLC6A2SLC6A3S1PR3NOS2 | |
| Fumaric Acid SCHEMBL6657327 | 0.90 | SLC6A2 (0.47) | SLC6A4SLC6A2SLC6A3S1PR3NOS2 | |
| Fumaric Acid SCHEMBL6657324 | 0.90 | SLC6A2 (0.47) | SLC6A4SLC6A2SLC6A3S1PR3NOS2 | |
| Fumaric Acid SCHEMBL5339512 | 0.88 | SLC6A2 (0.41) | SLC6A4SLC6A2SLC6A3S1PR3NOS2 | |
| Fumaric Acid SCHEMBL5339518 | 0.88 | SLC6A2 (0.41) | SLC6A4SLC6A2SLC6A3S1PR3NOS2 | |
| SCHEMBL5340734 | 0.86 | SLC6A4 (0.50) | SLC6A4SLC6A2SLC6A3NOS2KCNH2 | |
| Fumaric Acid SCHEMBL5345125 | 0.84 | SLC6A2 (0.44) | SLC6A4SLC6A2SLC6A3S1PR3NOS2 | |
| Fumaric Acid SCHEMBL5345121 | 0.84 | SLC6A2 (0.44) | SLC6A4SLC6A2SLC6A3S1PR3NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1434756-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2004-07-07 | — | — | EP | disclosed |
| WO-2003029185-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2003-04-10 | — | — | WO | disclosed |