Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TACR1 | P25103 | 1/20 | 0.45 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | RORC | P51449 | 1/20 | 0.44 |
| ▸ | STS | P08842 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | SFRP1 | Q8N474 | 2/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6696970 | 1.00 | SCN9A (0.47) | SCN9AMEN1KMT2ATACR1MMP13 | |
| SCHEMBL6694227 | 1.00 | SCN9A (0.47) | SCN9AMEN1KMT2ATACR1MMP13 | |
| SCHEMBL6688206 | 0.92 | SCN9A (0.46) | SCN9AMEN1KMT2ATACR1MMP13 | |
| SCHEMBL6688202 | 0.92 | SCN9A (0.46) | SCN9AMEN1KMT2ATACR1MMP13 | |
| SCHEMBL6688208 | 0.92 | SCN9A (0.46) | SCN9AMEN1KMT2ATACR1MMP13 | |
| SCHEMBL6848982 | 0.92 | SCN9A (0.46) | SCN9AMEN1KMT2ATACR1MMP13 | |
| SCHEMBL6694621 | 0.88 | SCN9A (0.49) | SCN9AMEN1KMT2ATACR1MMP13 | |
| SCHEMBL5459736 | 0.88 | SCN9A (0.49) | SCN9AMEN1KMT2ATACR1MMP13 | |
| SCHEMBL18345004 | 0.88 | SCN9A (0.49) | SCN9AMEN1KMT2ATACR1MMP13 | |
| SCHEMBL4760197 | 0.88 | SCN9A (0.49) | SCN9AMEN1KMT2ATACR1MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0812827-A1 | Piperidine derivative as intermediates for the preparation of paroxetine and process for their preparation | SUMIKA FINE CHEMICALS Co., Ltd. (JP) | 1997-12-17 | — | — | EP | claimed |
| US-6815548-B2 | MINTERMEDIATE FOR PHARMACEUTICALS SUCH AS PAROXETINE USEFUL AS ANTIDEPRESSANTS, REPRESENTED BY THE GENERAL FORMULA (I): | SUMIKA FINE CHEMICALS CO., LTD. (JP) | 2004-11-09 | — | — | US | disclosed |
| EP-1394160-A1 | Process for preparing crystalline paroxetin hydrochloride | SUMIKA FINE CHEMICALS Co., Ltd. (JP) | 2004-03-03 | — | — | EP | disclosed |
| EP-1384720-A1 | Process for drying paroxetine hydrochloride | SUMIKA FINE CHEMICALS Co., Ltd. (JP) | 2004-01-28 | — | — | EP | disclosed |
| EP-1384711-A1 | Optical resolution of a piperidine derivative | SUMIKA FINE CHEMICALS Co., Ltd. (JP) | 2004-01-28 | — | — | EP | disclosed |
| US-6610851-B1 | 1-tert-butoxycarbonyl-4-(4-fluorophenyl)-3-((3,4-methylene dioxyphenyl)oxymethyl)piperidine; reacting 4-(4-fluorophenyl)-3-hydroxymethylpiperidine with di-tert-butyl dicarbonate to form the carbamate; 3,4-methylenedioxyphenol | SUMIKA FINE CHEMICALS CO., LTD. (JP) | 2003-08-26 | — | — | US | disclosed |
| US-20030144519-A1 | Process for preparing a piperidine derivative | SUMIKA FINE CHEMICALS CO., LTD. | 2003-07-31 | — | — | US | disclosed |
| US-6476227-B1 | Piperidine derivative and process for preparing the same | SUMIKA FINE CHEMICALS CO., LTD. (JP) | 2002-11-05 | — | — | US | disclosed |
| US-5948914-A | PREPARING 4-(4-FLUOROPHENYL)-3-HYDROXYMETHYLPIPERIDINE BY OPTICALLY RESOLVING WITH O-CHLOROTARTRANILIC ACID; CHEMICAL INTERMEDIATE FOR DRUGS | SUMIKA FINE CHEMICALS CO., LTD. (JP) | 1999-09-07 | — | — | US | disclosed |
| EP-0812827-A1 | Piperidine derivative as intermediates for the preparation of paroxetine and process for their preparation | SUMIKA FINE CHEMICALS Co., Ltd. (JP) | 1997-12-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030144519-A1 | Process for preparing a piperidine derivative | TPH1, TPH2, HTR7 | SCN9A 1539/4885MEN1 4248/4885KMT2A 442/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.