Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.37 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6246108 | 0.96 | SMN1; SMN2 (0.51) | SMN1; SMN2ALDH1A1KDM4ERAB9ALMNA | |
| SCHEMBL6215019 | 0.87 | KMT2A (0.42) | SMN1; SMN2ALDH1A1KDM4ERAB9ALMNA | |
| SCHEMBL6217886 | 0.87 | ACHE (0.39) | SMN1; SMN2ALDH1A1KDM4ERAB9AHPGD | |
| SCHEMBL6219804 | 0.86 | HSD17B10 (0.45) | SMN1; SMN2ALDH1A1KDM4ERAB9AHPGD | |
| SCHEMBL6697362 | 0.80 | SMN1; SMN2 (0.51) | SMN1; SMN2ALDH1A1KDM4ERAB9ALMNA | |
| SCHEMBL4302257 | 0.79 | SMN1; SMN2 (0.74) | SMN1; SMN2ALDH1A1KDM4ERAB9ALMNA | |
| SCHEMBL6218814 | 0.79 | ACHE (0.39) | ALDH1A1HSD17B10ACHE | |
| SCHEMBL6667214 | 0.78 | KMT2A (0.43) | SMN1; SMN2ALDH1A1KDM4ELMNAHPGD | |
| SCHEMBL5781841 | 0.77 | HDAC1 (0.43) | ALDH1A1KDM4EHDAC1KMT2AACHE | |
| SCHEMBL5781219 | 0.77 | ACHE (0.39) | SMN1; SMN2ALDH1A1KDM4ELMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1414817-A1 | SUBSTITUTED ISOINDOLES AND E USE THEREOF | Bayer HealthCare AG (DE) | 2004-05-06 | — | — | EP | disclosed |
| WO-2003011858-A1 | SUBSTITUTED ISOINDOLES AND E USE THEREOF | BAYER HEALTHCARE AG (DE) | 2003-02-13 | — | — | WO | disclosed |