Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 3/20 | 0.42 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 5/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 2/20 | 0.31 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.31 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.31 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2878061 | 0.80 | NOTUM (0.38) | NOTUMARHTTHSD11B1MEN1 | |
| SCHEMBL1829864 | 0.78 | P2RX7 (0.40) | P2RX7EPAS1NOTUMARHSD11B1 | |
| SCHEMBL10493630 | 0.78 | P2RX7 (0.40) | P2RX7NOTUMARHSD11B1 | |
| SCHEMBL5735761 | 0.77 | NOTUM (0.36) | NOTUMHTTHSD11B1MEN1NPC1 | |
| SCHEMBL9912399 | 0.77 | P2RX7 (0.39) | P2RX7EPAS1ARHSD11B1TMPRSS4 | |
| SCHEMBL23226966 | 0.75 | TMPRSS4 (0.41) | P2RX7ARCTSSTMPRSS4 | |
| SCHEMBL17274386 | 0.75 | NOTUM (0.35) | NOTUMHTTHSD11B1MEN1NPC1 | |
| SCHEMBL669762 | 0.75 | P2RX7 (0.42) | P2RX7EPAS1NOTUMHSD11B1SMN1; SMN2 | |
| SCHEMBL18935992 | 0.75 | P2RX7 (0.38) | P2RX7EPAS1NOTUMENPP3ENPP1 | |
| SCHEMBL669761 | 0.75 | P2RX7 (0.42) | P2RX7EPAS1NOTUMHSD11B1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2605658-A1 | SPIROXAZOLIDINONE COMPOUNDS | Merck Sharp & Dohme Corp. (US) | 2013-06-26 | — | — | EP | disclosed |
| WO-2012024183-A1 | SPIROXAZOLIDINONE COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2012-02-23 | — | — | WO | disclosed |