Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.42 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.33 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.31 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.31 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL669762 | 1.00 | P2RX7 (0.42) | P2RX7EPAS1NOTUMENPP3ENPP1 | |
| SCHEMBL669763 | 0.75 | P2RX7 (0.42) | P2RX7EPAS1NOTUMENPP3ENPP1 | |
| SCHEMBL18935992 | 0.75 | P2RX7 (0.38) | P2RX7EPAS1NOTUMENPP3ENPP1 | |
| SCHEMBL29434877 | 0.74 | P2RX7 (0.53) | P2RX7EPAS1NOTUMENPP3ENPP1 | |
| SCHEMBL1410137 | 0.74 | P2RX7 (0.53) | P2RX7EPAS1NOTUMENPP3ENPP1 | |
| SCHEMBL10974687 | 0.72 | EPAS1 (0.37) | P2RX7EPAS1NOTUMENPP3ENPP1 | |
| SCHEMBL30053746 | 0.72 | EPAS1 (0.37) | P2RX7EPAS1NOTUMENPP3ENPP1 | |
| SCHEMBL18797703 | 0.71 | TNF (0.33) | — | |
| SCHEMBL18797704 | 0.71 | TNF (0.33) | — | |
| SCHEMBL23846815 | 0.71 | TDP1 (0.39) | P2RX7EPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2605658-A1 | SPIROXAZOLIDINONE COMPOUNDS | Merck Sharp & Dohme Corp. (US) | 2013-06-26 | — | — | EP | disclosed |
| WO-2012024183-A1 | SPIROXAZOLIDINONE COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2012-02-23 | — | — | WO | disclosed |