SCHEMBL6697966

SCHEMBL6697966

CCCCOc1cccc2sc(SNC(C)(C)C)nc12

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.43
ALDH1A1 P00352 3/20 0.43
KDM4E B2RXH2 3/20 0.43
MEN1 O00255 3/20 0.43
MAPT P10636 2/20 0.43
TDP1 Q9NUW8 2/20 0.43
PKM P14618 1/20 0.43
MAPK1 P28482 1/20 0.43
MCHR1 Q99705 4/20 0.42
EPHX2 P34913 1/20 0.40
DUSP3 P51452 1/20 0.38
TP53 P04637 2/20 0.37
CNR2 P34972 1/20 0.35
HPGD P15428 1/20 0.35
HTT P42858 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
GAA P10253 1/20 0.35
CYP1A2 P05177 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6689073 0.94 KMT2A (0.44) KMT2AALDH1A1KDM4EMEN1MAPT
SCHEMBL6693674 0.89 ALDH1A1 (0.56) KMT2AALDH1A1KDM4EMEN1MAPT
SCHEMBL6694180 0.85 KMT2A (0.45) KMT2AALDH1A1KDM4EMEN1MAPT
SCHEMBL6899949 0.83 ALDH1A1 (0.50) KMT2AALDH1A1KDM4EMEN1MAPT
SCHEMBL6690900 0.83 ALDH1A1 (0.50) KMT2AALDH1A1KDM4EMEN1MAPT
SCHEMBL6689383 0.82 ALDH1A1 (0.52) KMT2AALDH1A1KDM4EMEN1MAPT
SCHEMBL6697899 0.81 HSP90AA1 (0.42) ALDH1A1MCHR1CNR2CYP1A2CYP2C9
SCHEMBL6689479 0.79 ALDH1A1 (0.53) KMT2AALDH1A1KDM4EMEN1MAPT
SCHEMBL29683632 0.78 MEN1 (0.36) KMT2AALDH1A1KDM4EMEN1MAPT
SCHEMBL6694175 0.78 MEN1 (0.36) KMT2AALDH1A1KDM4EMEN1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0869016-B1 Pneumatic radial tires BRIDGESTONE CORP (JP) 2004-03-03 EP disclosed
EP-0945482-B1 Rubber composition for tire tread and pneumatic tire using same BRIDGESTONE CORP (JP) 2004-01-28 EP disclosed
EP-0890605-B1 Pneumatic tire BRIDGESTONE CORP (JP) 2003-04-23 EP disclosed
EP-0854168-B1 Rubber composition BRIDGESTONE CORP (JP) 2003-04-02 EP disclosed
EP-1277795-A2 Pneumatic tire BRIDGESTONE CORPORATION (JP) 2003-01-22 EP disclosed
US-20020010283-A1 RUBBER COMPOSITION BRIDGESTONE CORPORATION (JP) 2002-01-24 US disclosed
US-6336486-B1 Pneumatic radical tire having cap base tread BRIDGESTONE CORPORATION (JP) 2002-01-08 US disclosed
US-6242522-B1 A DIENE BASED SYNTHETIC RUBBER OR NATURAL RUBBER BLEND CONTAINING BUTADIENE-STYRENE RUBBER, ALUMINUM HYDROXIDE POWDER, SILICA POWDER, CARBON BLACK; LOW FUEL CONSUMPTION AND WEAR RESISTANCE; IMPROVED GRIPPING IN WET AND COLD SITUATIONS BRIDGESTONE CORPORATION (JP) 2001-06-05 US disclosed
US-6186204-B1 EXCELLENT STABILITY AND CONTROLLABILITY ON WET ROADS OR A COMBINATION OF STABILITY AND CONTROLLABILITY ON WET ROADS AND EXCELLENT COMFORT OF RIDE EVEN WHEN A VEHICLE IS VIBRATING THROUGHOUT THE LIFE OF THE PNEUMATIC TIRE BRIDGESTONE CORPORATION (JP) 2001-02-13 US disclosed
EP-0948029-A2 High pressure discharge lamp NGK INSULATORS, LTD. (JP) 1999-10-06 EP disclosed
EP-0890605-A2 Pneumatic tire BRIDGESTONE CORPORATION (JP) 1999-01-13 EP disclosed
EP-0869016-A2 Pneumatic radial tires Bridgestone Corporation (JP) 1998-10-07 EP disclosed
EP-0854168-A1 Rubber composition Bridgestone Corporation (JP) 1998-07-22 EP disclosed