SCHEMBL6697899

SCHEMBL6697899

CCCCOc1cccc2nc(SNC(C)(C)C)sc12

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 7/20 0.42
HSP90AB1 P08238 7/20 0.42
MCHR1 Q99705 3/20 0.37
TLR8 Q9NR97 3/20 0.37
CSNK1A1 P48729 1/20 0.36
CSNK1D P48730 1/20 0.36
PRKCD Q05655 1/20 0.36
PAK1 Q13153 1/20 0.36
CAMK2B Q13554 1/20 0.36
CAMK2G Q13555 1/20 0.36
CAMK2D Q13557 1/20 0.36
TAOK1 Q7L7X3 1/20 0.36
CNR2 P34972 1/20 0.35
CYP1A2 P05177 2/20 0.35
CYP2C19 P33261 2/20 0.35
CYP2C9 P11712 1/20 0.35
PTGS2 P35354 1/20 0.34
NCF1 P14598 1/20 0.33
NPC1 O15118 1/20 0.33
ALDH1A1 P00352 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6689394 0.89 HSP90AA1 (0.44) HSP90AA1HSP90AB1TLR8ALDH1A1SMN1; SMN2
SCHEMBL6694319 0.85 HSP90AA1 (0.43) HSP90AA1HSP90AB1MCHR1TLR8CSNK1A1
SCHEMBL6694187 0.83 HSP90AA1 (0.49) HSP90AA1HSP90AB1MCHR1TLR8CSNK1A1
SCHEMBL6697802 0.83 HSP90AA1 (0.39) HSP90AA1HSP90AB1PTGS2NPC1ALDH1A1
SCHEMBL6697966 0.81 KMT2A (0.43) MCHR1CNR2CYP1A2CYP2C19CYP2C9
SCHEMBL6690259 0.79 ALDH1A1 (0.53) HSP90AA1HSP90AB1CNR2ALDH1A1
SCHEMBL6690919 0.75 PPARA (0.43) CYP1A2CYP2C19CYP2C9
SCHEMBL6689073 0.75 KMT2A (0.44) MCHR1ALDH1A1
SCHEMBL6691037 0.75 PPARA (0.51) NPC1ALDH1A1RAB9A
SCHEMBL6690756 0.74 MCHR1 (0.47) HSP90AA1HSP90AB1MCHR1TLR8CSNK1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0869016-B1 Pneumatic radial tires BRIDGESTONE CORP (JP) 2004-03-03 EP disclosed
EP-0945482-B1 Rubber composition for tire tread and pneumatic tire using same BRIDGESTONE CORP (JP) 2004-01-28 EP disclosed
EP-0890605-B1 Pneumatic tire BRIDGESTONE CORP (JP) 2003-04-23 EP disclosed
EP-1277795-A2 Pneumatic tire BRIDGESTONE CORPORATION (JP) 2003-01-22 EP disclosed
US-20020010283-A1 RUBBER COMPOSITION BRIDGESTONE CORPORATION (JP) 2002-01-24 US disclosed
US-6336486-B1 Pneumatic radical tire having cap base tread BRIDGESTONE CORPORATION (JP) 2002-01-08 US disclosed
US-6242522-B1 A DIENE BASED SYNTHETIC RUBBER OR NATURAL RUBBER BLEND CONTAINING BUTADIENE-STYRENE RUBBER, ALUMINUM HYDROXIDE POWDER, SILICA POWDER, CARBON BLACK; LOW FUEL CONSUMPTION AND WEAR RESISTANCE; IMPROVED GRIPPING IN WET AND COLD SITUATIONS BRIDGESTONE CORPORATION (JP) 2001-06-05 US disclosed
US-6186204-B1 EXCELLENT STABILITY AND CONTROLLABILITY ON WET ROADS OR A COMBINATION OF STABILITY AND CONTROLLABILITY ON WET ROADS AND EXCELLENT COMFORT OF RIDE EVEN WHEN A VEHICLE IS VIBRATING THROUGHOUT THE LIFE OF THE PNEUMATIC TIRE BRIDGESTONE CORPORATION (JP) 2001-02-13 US disclosed
EP-0948029-A2 High pressure discharge lamp NGK INSULATORS, LTD. (JP) 1999-10-06 EP disclosed
EP-0890605-A2 Pneumatic tire BRIDGESTONE CORPORATION (JP) 1999-01-13 EP disclosed
EP-0869016-A2 Pneumatic radial tires Bridgestone Corporation (JP) 1998-10-07 EP disclosed
EP-0854168-A1 Rubber composition Bridgestone Corporation (JP) 1998-07-22 EP disclosed