Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 6/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | QRFPR | Q96P65 | 1/20 | 0.50 |
| ▸ | MPO | P05164 | 8/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SLC9A3 | P48764 | 2/20 | 0.45 |
| ▸ | PLG | P00747 | 1/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | PLAT | P00750 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27571646 | 0.88 | RAD52 (0.50) | RAD52KMT2APOLBKDM4ESMN1; SMN2 | |
| SCHEMBL6695186 | 0.84 | KMT2A (0.77) | RAD52KMT2APOLBKDM4ESMN1; SMN2 | |
| SCHEMBL6693942 | 0.79 | RAD52 (0.74) | RAD52KMT2APOLBKDM4ESMN1; SMN2 | |
| SCHEMBL6695085 | 0.79 | KMT2A (0.79) | RAD52KMT2APOLBKDM4ESMN1; SMN2 | |
| SCHEMBL6697414 | 0.78 | POLB (0.68) | RAD52KMT2APOLBKDM4EMPO | |
| SCHEMBL6701733 | 0.78 | RAD52 (0.81) | RAD52KMT2APOLBKDM4ESMN1; SMN2 | |
| SCHEMBL6696507 | 0.78 | RAD52 (0.51) | RAD52KMT2APOLBKDM4ESMN1; SMN2 | |
| SCHEMBL6695249 | 0.76 | KDM4E (0.71) | RAD52KMT2APOLBKDM4ESMN1; SMN2 | |
| SCHEMBL6698066 | 0.76 | HSP90AB1 (0.41) | KMT2AKDM4ESMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL6695258 | 0.75 | RAD52 (0.72) | RAD52KMT2APOLBKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040224965-A1 | 2-Guanidino-4-arylchinazolines as nhe-3 inhibitors | MERCK PATENT GMBH (DE) | 2004-11-11 | — | — | US | claimed |
| US-20040224965-A1 | 2-Guanidino-4-arylchinazolines as nhe-3 inhibitors | MERCK PATENT GMBH (DE) | 2004-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040224965-A1 | 2-Guanidino-4-arylchinazolines as nhe-3 inhibitors | NHERF1, SLC9A3, SLC9A1 | RAD52 4856/4885KMT2A 3326/4885POLB 4015/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.