Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 15/20 | 0.48 |
| ▸ | MMP1 | P03956 | 13/20 | 0.48 |
| ▸ | MMP2 | P08253 | 7/20 | 0.48 |
| ▸ | MMP3 | P08254 | 4/20 | 0.48 |
| ▸ | MMP9 | P14780 | 4/20 | 0.48 |
| ▸ | MMP8 | P22894 | 2/20 | 0.41 |
| ▸ | MMP14 | P50281 | 2/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | MMP7 | P09237 | 1/20 | 0.37 |
| ▸ | MMP10 | P09238 | 1/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6692070 | 0.88 | MMP13 (0.51) | MMP13MMP1MMP2MMP3MMP9 | |
| SCHEMBL6694370 | 0.85 | MMP13 (0.54) | MMP13MMP1MMP2MMP3MMP9 | |
| SCHEMBL6693912 | 0.82 | MMP13 (0.50) | MMP13MMP1MMP2MMP3MMP9 | |
| SCHEMBL6689106 | 0.79 | S1PR5 (0.41) | MMP13MMP1MMP2MMP3MMP9 | |
| SCHEMBL6690999 | 0.74 | MMP13 (0.58) | MMP13MMP1MMP2MMP3MMP9 | |
| SCHEMBL6698909 | 0.73 | S1PR5 (0.40) | MMP13MMP1MMP2MMP3MMP9 | |
| SCHEMBL6697906 | 0.72 | MMP13 (0.69) | MMP13MMP1MMP2MMP3MMP9 | |
| SCHEMBL6689447 | 0.71 | MMP1 (0.38) | MMP13MMP1MMP2MMP3MMP9 | |
| SCHEMBL6693880 | 0.70 | MMP1 (0.57) | MMP13MMP1MMP2MMP3MMP9 | |
| SCHEMBL6703207 | 0.69 | MMP13 (0.53) | MMP13MMP1MMP2MMP3MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1134215-B1 | 2-oxo-imidazolidine-4-carboxylic acid hydroxamine compounds that inhibit matrix metalloproteinases | PFIZER PROD INC (US) | 2004-10-06 | — | — | EP | claimed |