Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 2/20 | 0.34 |
| ▸ | CCR1 | P32246 | 1/20 | 0.33 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
| ▸ | CCR8 | P51685 | 1/20 | 0.33 |
| ▸ | HPGDS | O60760 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25519639 | 0.73 | CCR1 (0.67) | ABCG2PARP1CCR1CCR5CCR8 | |
| SCHEMBL7082437 | 0.73 | ABCG2 (0.37) | ABCG2PARP1CCR1CCR5CCR8 | |
| SCHEMBL28012715 | 0.73 | ABCG2 (0.37) | ABCG2CCR1CCR5CCR8 | |
| SCHEMBL29801578 | 0.73 | TET2 (0.44) | ABCG2CCR1CCR5CCR8 | |
| SCHEMBL12483903 | 0.73 | TET2 (0.44) | ABCG2CCR1CCR5CCR8 | |
| SCHEMBL12483271 | 0.73 | ABCG2 (0.40) | ABCG2CCR1CCR5CCR8 | |
| SCHEMBL28088161 | 0.73 | ABCG2 (0.37) | ABCG2CCR1CCR5CCR8 | |
| SCHEMBL6698156 | 0.72 | ABCG2 (0.38) | ABCG2PARP1CCR1CCR5CCR8 | |
| SCHEMBL29940529 | 0.71 | PSMD14 (0.53) | ABCG2 | |
| SCHEMBL7085565 | 0.70 | PSMD14 (0.54) | ABCG2PARP1HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0992509-B1 | Novel macrolide derivatives | PFIZER PROD INC (US) | 2004-09-22 | — | — | EP | disclosed |
| US-6100240-A | USEFUL AS ANTIBACTERIAL AGENTS AND ANTIPROTOZOA AGENTS | PFIZER INC (US) | 2000-08-08 | — | — | US | disclosed |
| EP-0992509-A2 | Novel macrolide derivatives | Pfizer Products Inc. (US) | 2000-04-12 | — | — | EP | disclosed |
| US-6043226-A | TREATING BACTERIAL, PARASITIC AND PROTOZOAL INFECTIONS | PFIZER INC. (US) | 2000-03-28 | — | — | US | disclosed |