Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | TTR | P02766 | 1/20 | 0.33 |
| ▸ | ALB | P02768 | 1/20 | 0.33 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16518103 | 0.79 | ERN1 (0.46) | ERN1PIM1PIM3TDP1ALDH1A1 | |
| SCHEMBL16616202 | 0.79 | ERN1 (0.40) | ERN1PIM1PIM3NFE2L2ALDH1A1 | |
| SCHEMBL19154298 | 0.75 | NFE2L2 (0.47) | ERN1PIM1PIM3NFE2L2TDP1 | |
| SCHEMBL96915 | 0.75 | NFE2L2 (0.54) | ERN1NFE2L2ALDH1A1KDM4EPTPN1 | |
| SCHEMBL29824365 | 0.75 | NFE2L2 (0.54) | ERN1NFE2L2ALDH1A1KDM4EPTPN1 | |
| SCHEMBL16616115 | 0.75 | ERN1 (0.49) | ERN1PIM1PIM3ALDH1A1KDM4E | |
| SCHEMBL505574 | 0.74 | PIM1 (0.50) | ERN1PIM1PIM3NFE2L2ALDH1A1 | |
| SCHEMBL6495322 | 0.73 | TDP1 (0.46) | ERN1TDP1LMNAMEN1KMT2A | |
| SCHEMBL16616040 | 0.72 | ERN1 (0.42) | ERN1ALDH1A1MEN1CA1CA2 | |
| SCHEMBL14879562 | 0.72 | ALDH1A1 (0.49) | NFE2L2ALDH1A1KDM4ELMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2605658-A1 | SPIROXAZOLIDINONE COMPOUNDS | Merck Sharp & Dohme Corp. (US) | 2013-06-26 | — | — | EP | disclosed |
| WO-2012024183-A1 | SPIROXAZOLIDINONE COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2012-02-23 | — | — | WO | disclosed |