⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31125022 | 0.80 | HPGD (0.53) | — | |
| SCHEMBL3048551 | 0.77 | HPGD (0.50) | — | |
| SCHEMBL9038779 | 0.77 | RAB9A (0.51) | — | |
| SCHEMBL2164071 | 0.68 | HPGD (0.36) | — | |
| Hydrochloric Acid SCHEMBL6993968 | 0.67 | MAOA (0.43) | — | |
| SCHEMBL13865329 | 0.67 | BRD4 (0.50) | — | |
| SCHEMBL5025454 | 0.67 | NPC1 (0.41) | — | |
| SCHEMBL31021243 | 0.67 | PNMT (0.42) | — | |
| SCHEMBL6626771 | 0.67 | — | — | |
| SCHEMBL8272673 | 0.66 | HPGD (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116478179-B | Thienopyrrolidone derivative as well as preparation method and application thereof | 平湖市浙江工业大学新材料研究院 | 2024-12-06 | — | — | CN | claimed |
| CN-116478179-A | Thienopyrrolidone derivative as well as preparation method and application thereof | 平湖市浙江工业大学新材料研究院 | 2023-07-25 | — | — | CN | claimed |
| CN-116396471-A | Ext> IIGext> -ext> Aext> doubleext> -ext> receptorext> conjugatedext> polymerext> andext> syntheticext> methodext> thereofext> | 中国科学院成都有机化学有限公司 | 2023-07-07 | — | — | CN | claimed |
| CN-119330982-A | Azetidine compound and medical application thereof | 中国科学院上海药物研究所 | 2025-01-21 | — | — | CN | disclosed |
| CN-116478179-B | Thienopyrrolidone derivative as well as preparation method and application thereof | 平湖市浙江工业大学新材料研究院 | 2024-12-06 | — | — | CN | disclosed |
| CN-116478179-B | Thienopyrrolidone derivative as well as preparation method and application thereof | 平湖市浙江工业大学新材料研究院 | 2024-12-06 | — | — | CN | disclosed |
| CN-116478179-B | Thienopyrrolidone derivative as well as preparation method and application thereof | 平湖市浙江工业大学新材料研究院 | 2024-12-06 | — | — | CN | disclosed |
| CN-117510800-A | Preparation method of thienopyrrole diketone polymer | 大连理工大学 | 2024-02-06 | — | — | CN | disclosed |
| CN-116751190-A | Sulfonyl derivative organic luminescent material and preparation method and application thereof | 华南理工大学 | 2023-09-15 | — | — | CN | disclosed |
| CN-116606284-A | Benzophenone derivative organic luminescent material and preparation method and application thereof | 华南理工大学 | 2023-08-18 | — | — | CN | disclosed |
| CN-115286774-B | Double-cable polymer containing thienopyrrolidone side chain groups, and preparation method and application thereof | 北京化工大学 | 2023-08-11 | — | — | CN | disclosed |
| EP-1301517-B1 | THIENOPYRROLIDINONES | HOFFMANN LA ROCHE (CH) | 2004-12-15 | — | — | EP | disclosed |
| CN-1440412-A | Thienopyrrolidinones | HOFFMANN LA ROCHE (CH) | 2003-09-03 | — | — | CN | disclosed |
| CN-1440412-A | Thienopyrrolidinones | HOFFMANN LA ROCHE (CH) | 2003-09-03 | — | — | CN | disclosed |
| EP-1301517-A1 | THIENOPYRROLIDINONES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-16 | — | — | EP | disclosed |
| US-6528653-B2 | E.g., 4,6-dihydro 4-(heterocyclic ring-methylene)thieno(2,3-b) pyrrolidin-5-one derivatives; tumor necrosis factor ) inhibitors; anticarcinogenic, -proliferative and -arthritic agents; Alzheimer's disease; cardiovascular disorders | HOFFMANN-LA ROCHE, INC. | 2003-03-04 | — | — | US | disclosed |
| US-6528653-B2 | E.g., 4,6-dihydro 4-(heterocyclic ring-methylene)thieno(2,3-b) pyrrolidin-5-one derivatives; tumor necrosis factor ) inhibitors; anticarcinogenic, -proliferative and -arthritic agents; Alzheimer's disease; cardiovascular disorders | HOFFMANN-LA ROCHE, INC. | 2003-03-04 | — | — | US | disclosed |
| US-20020028841-A1 | Thienopyrrolidinones | F. HOFFMANN-LA ROCHE AG (CH) | 2002-03-07 | — | — | US | disclosed |
| US-20020028841-A1 | Thienopyrrolidinones | F. HOFFMANN-LA ROCHE AG (CH) | 2002-03-07 | — | — | US | disclosed |
| WO-2002002567-A1 | THIENOPYRROLIDINONES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-10 | — | — | WO | disclosed |