Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 15/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.82 |
| ▸ | MEN1 | O00255 | 9/20 | 0.82 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.82 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.82 |
| ▸ | RAB9A | P51151 | 1/20 | 0.82 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.82 |
| ▸ | TP53 | P04637 | 2/20 | 0.74 |
| ▸ | MST1R | Q04912 | 1/20 | 0.74 |
| ▸ | GAA | P10253 | 12/20 | 0.71 |
| ▸ | POLB | P06746 | 2/20 | 0.70 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.70 |
| ▸ | HTT | P42858 | 1/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.69 |
| ▸ | LMNA | P02545 | 3/20 | 0.66 |
| ▸ | HPGD | P15428 | 3/20 | 0.66 |
| ▸ | CASP1 | P29466 | 2/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | BLM | P54132 | 1/20 | 0.65 |
| ▸ | PLEC | Q15149 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13166883 | 0.85 | MST1R (1.00) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL5646856 | 0.77 | TP53 (0.69) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL22144484 | 0.76 | GAA (1.00) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL10077846 | 0.76 | MAPT (1.00) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL10077845 | 0.76 | GAA (1.00) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL4420851 | 0.75 | ALDH1A1 (0.74) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL4425365 | 0.75 | ALDH1A1 (0.74) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL6698946 | 0.75 | MAPT (1.00) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL6701145 | 0.75 | KDM4E (0.77) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL4418592 | 0.75 | KDM4E (0.77) | MAPTALDH1A1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7279470-B2 | Compounds and uses thereof for decreasing activity of hormone-sensitive lipase | NOVO NORDISK A/S (DK) | 2007-10-09 | — | — | US | disclosed |
| US-7067517-B2 | Use of compounds for decreasing activity of hormone-sensitive lipase | NERO NORDISK A/S (DK) | 2006-06-27 | — | — | US | disclosed |
| EP-1458375-A2 | COMPOSITIONS FOR DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE | NOVO NORDISK A/S (DK) | 2004-09-22 | — | — | EP | disclosed |
| EP-1458374-A2 | COMPOUNDS AND USES THEREOF FOR DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE | NOVO NORDISK A/S (DK) | 2004-09-22 | — | — | EP | disclosed |
| US-20030166644-A1 | Compounds and uses thereof for decreasing activity of hormone-sensitive lipase | NOVO NORDISK A/S (DK) | 2003-09-04 | — | — | US | disclosed |
| US-20030166690-A1 | Use of compounds for decreasing activity of hormone-sensitive | NOVO NORDISK A/S (DK) | 2003-09-04 | — | — | US | disclosed |
| WO-2003051842-A2 | COMPOSITIONS DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE | NOVO NORDISK A/S (DK) | 2003-06-26 | — | — | WO | disclosed |
| WO-2003051841-A2 | COMPOUNDS AND USES THEREOF FOR DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE | NOVO NORDISK A/S (DK) | 2003-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030166644-A1 | Compounds and uses thereof for decreasing activity of hormone-sensitive lipase | LIPE, PNLIP, LPL | MAPT 4693/4885ALDH1A1 1304/4885MEN1 2277/4885 |
| US-20030166690-A1 | Use of compounds for decreasing activity of hormone-sensitive | LIPE, PNLIP, LPL | MAPT 4668/4885ALDH1A1 1599/4885MEN1 1767/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.