SCHEMBL669957

SCHEMBL669957

CN(C)c1cc(O)c(-c2ccccc2)c(N(C)C)c1N(C)C

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE4B Q07343 4/20 0.39
PDE4A P27815 3/20 0.39
PDE4C Q08493 3/20 0.39
PDE4D Q08499 3/20 0.39
HDAC4 P56524 1/20 0.39
HDAC2 Q92769 1/20 0.39
HDAC8 Q9BY41 1/20 0.39
MAPT P10636 2/20 0.38
KDM4E B2RXH2 1/20 0.38
EP300 Q09472 1/20 0.38
KAT2B Q92831 1/20 0.38
KAT8 Q9H7Z6 1/20 0.38
BACE1 P56817 1/20 0.38
HTT P42858 1/20 0.38
MEN1 O00255 1/20 0.37
GAA P10253 1/20 0.37
TSHR P16473 1/20 0.37
KMT2A Q03164 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
ALOX5 P09917 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11409328 0.71 MAPT (0.43) PDE4BPDE4APDE4CPDE4DMAPT
SCHEMBL19929763 0.69 MAPT (0.42) PDE4BPDE4APDE4CPDE4DMAPT
SCHEMBL4028857 0.69 ACHE (0.39) EP300KAT2BKAT8APP
SCHEMBL8951481 0.68 ALOX5 (0.57) HDAC4HDAC2HDAC8MAPTKDM4E
SCHEMBL28285937 0.68 MAPT (0.50) MAPTKDM4EHTTGAATSHR
SCHEMBL25456081 0.67 MAPT (0.40) MAPTKDM4EHTTMEN1KMT2A
SCHEMBL19929762 0.67 MAPT (0.43) MAPTKDM4EBACE1HTTMEN1
SCHEMBL7915840 0.66 ALDH1A1 (0.53) HDAC4HDAC2HDAC8MAPTKDM4E
SCHEMBL28583369 0.65 NQO1 (0.59) PDE4BPDE4APDE4CPDE4DMAPT
SCHEMBL31545354 0.65 ALOX5 (0.58) PDE4BPDE4APDE4CPDE4DHDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2606074-B1 CURABLE POLYMER MIXTURE BYK CHEMIE GMBH (DE) 2014-07-23 EP disclosed
EP-2606074-A1 CURABLE POLYMER MIXTURE BYK-Chemie GmbH (DE) 2013-06-26 EP disclosed
US-8153722-B2 Curable polymer concrete mixture BYK-CHEMIE GMBH (DE) 2012-04-10 US disclosed
WO-2012022436-A1 CURABLE POLYMER MIXTURE BYK-CHEMIE GMBH (DE) 2012-02-23 WO disclosed
EP-2125657-B1 CURABLE POLYMER MIXTURE BYK CHEMIE GMBH (DE) 2011-09-07 EP disclosed
US-20100016492-A1 CURABLE POLYMER CONCRETE MIXTURE BYK-CHEMIE GMBH (DE) 2010-01-21 US disclosed
EP-2125657-A1 CURABLE POLYMER CONCRETE MIXTURE Byk-Chemie GmbH (DE) 2009-12-02 EP disclosed
WO-2008104378-A1 CURABLE POLYMER CONCRETE MIXTURE BYK-CHEMIE GMBH (DE) 2008-09-04 WO disclosed