Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 2/20 | 0.40 |
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.39 |
| ▸ | MMP2 | P08253 | 2/20 | 0.38 |
| ▸ | HRH2 | P25021 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PLG | P00747 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.37 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.37 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4052607 | 0.86 | MMP13 (0.43) | MEN1KMT2AMMP13MMP12PARP10 | |
| SCHEMBL6700688 | 0.82 | MMP13 (0.42) | MEN1KMT2AMMP13MMP12PARP10 | |
| SCHEMBL6677177 | 0.80 | MMP12 (0.59) | MMP13MMP12ADAM17MMP2 | |
| SCHEMBL6700679 | 0.78 | MMP12 (0.42) | MEN1KMT2AMMP13MMP12PARP10 | |
| SCHEMBL6692739 | 0.78 | MEN1 (0.40) | MEN1KMT2AKDM4EMAPT | |
| SCHEMBL4050014 | 0.74 | MMP13 (0.59) | MMP13MMP12ADAM17MMP2 | |
| SCHEMBL6595548 | 0.70 | ADAM17 (0.65) | MMP13MMP12ADAM17MMP2 | |
| SCHEMBL6688203 | 0.70 | MMP13 (0.51) | MMP13MMP12ADAM17MMP2 | |
| SCHEMBL4056893 | 0.67 | MMP12 (0.60) | MMP13MMP12ADAM17MMP2 | |
| Trifluoroacetic Acid SCHEMBL6598038 | 0.67 | ADAM17 (0.60) | MMP13ADAM17MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397137-A4 | HYDANTION DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES | BRISTOL MYERS SQUIBB CO (US) | 2004-10-13 | — | — | EP | disclosed |
| EP-1397137-A1 | HYDANTION DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-03-17 | — | — | EP | disclosed |
| WO-2002096426-A1 | HYDANTION DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-12-05 | — | — | WO | disclosed |