Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | TPMT | P51580 | 1/20 | 0.45 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.44 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5691398 | 0.90 | TPMT (0.49) | TSHRMAPK1ALDH1A1TPMTGRIN2D | |
| SCHEMBL7042203 | 0.84 | TSHR (0.44) | TSHRMAPK1ALDH1A1TPMTGRIN2D | |
| SCHEMBL28043007 | 0.84 | MAPK1 (0.49) | TSHRMAPK1ALDH1A1TPMTGRIN2D | |
| SCHEMBL10425942 | 0.82 | TPMT (0.43) | TSHRMAPK1ALDH1A1TPMTMAPT | |
| SCHEMBL7045447 | 0.82 | MAPT (0.53) | TSHRMAPK1ALDH1A1TPMTGRIN2D | |
| SCHEMBL12087101 | 0.82 | TPMT (0.43) | TSHRMAPK1ALDH1A1TPMTMAPT | |
| SCHEMBL20523543 | 0.82 | TPMT (0.43) | TSHRMAPK1ALDH1A1TPMTGRIN2D | |
| SCHEMBL29161426 | 0.82 | TPMT (0.43) | TSHRMAPK1ALDH1A1TPMTGRIN2D | |
| SCHEMBL11741963 | 0.80 | TDP1 (0.41) | TSHRMAPK1ALDH1A1TPMTMAPT | |
| SCHEMBL17744425 | 0.80 | ALDH1A1 (0.47) | TSHRMAPK1ALDH1A1TPMTGRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8084459-B2 | 8-hydroxy-3H-quinazolin-4-(thi)one derivatives; ability to enter CNS, sequester transition metals Cu, Zn and Fe from various amiloid beta entities, reducing their toxicity; neurodegenerative disorders; Alzheimer's, Parkinson's, Cruetzfeldt-Jacob diseases, amyotrophic lateral sclerosis, cataract | PRANA BIOTECHNOLOGY LTD (AU) | 2011-12-27 | — | — | US | disclosed |
| US-8084459-B2 | 8-hydroxy-3H-quinazolin-4-(thi)one derivatives; ability to enter CNS, sequester transition metals Cu, Zn and Fe from various amiloid beta entities, reducing their toxicity; neurodegenerative disorders; Alzheimer's, Parkinson's, Cruetzfeldt-Jacob diseases, amyotrophic lateral sclerosis, cataract | PRANA BIOTECHNOLOGY LTD (AU) | 2011-12-27 | — | — | US | disclosed |
| US-20080119470-A1 | Neurologically-Active Compounds | XOMA TECHNOLOGY LTD. | 2008-05-22 | — | — | US | disclosed |
| US-20080119470-A1 | Neurologically-Active Compounds | XOMA TECHNOLOGY LTD. | 2008-05-22 | — | — | US | disclosed |
| WO-2005095360-A1 | NEUROLOGICALLY-ACTIVE COMPOUNDS | PRANA BIOTECHNOLOGY LIMITED (AU) | 2005-10-13 | — | — | WO | disclosed |
| US-20040034036-A1 | N-(3,5-dichloro-2-methoxyphenyl)-4-methoxy-3-piperazin-1-yl-benzenesulfonamide | SMITHKLINE BEECHMAN P.L.C. (GB) | 2004-02-19 | — | — | US | disclosed |
| WO-2003072198-A1 | THE USE OF A BENZENESULFONAMIDE COMPOUND IN THE TREATMENT OF OBESITY | GLAXO GROUP LIMITED (GB) | 2003-09-04 | — | — | WO | disclosed |
| US-6613786-B2 | Treating urinary incontinence, asthma, irritable bowel syndrome or male erectile dysfunction | BRISTOL-MYERS SQUIBB COMPANY | 2003-09-02 | — | — | US | disclosed |
| US-20030144333-A1 | Thiophenyl triazol-3-one derivatives as smooth muscle relaxants | HEWAWASAM PIYASENA (US) | 2003-07-31 | — | — | US | disclosed |
| EP-1313720-A1 | N-(3,5-DICHLORO-2-METHOXYPHENYL)-4-METHOXY-3-PIPERAZIN-1-YL-BENZENESULFONAMIDE | SMITHKLINE BEECHAM PLC (GB) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002018358-A1 | N-(3,5-DICHLORO-2-METHOXYPHENYL)-4-METHOXY-3-PIPERAZIN-1-YL-BENZENESULFONAMIDE | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-03-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080119470-A1 | Neurologically-Active Compounds | ACHE, PSEN1, PSEN2 | TSHR 4660/4885MAPK1 2356/4885ALDH1A1 1120/4885 |
| US-20040034036-A1 | N-(3,5-dichloro-2-methoxyphenyl)-4-methoxy-3-piperazin-1-yl-benzenesulfonamide | PMP22, CNR2, SNCA | TSHR 2110/4885MAPK1 3099/4885ALDH1A1 964/4885 |
| US-20030144333-A1 | Thiophenyl triazol-3-one derivatives as smooth muscle relaxants | PDE3A, ADRB2, ADRB3 | TSHR 1867/4885MAPK1 1634/4885ALDH1A1 1237/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.