Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | XPO1 | O14980 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6288769 | 0.81 | MAPT (0.39) | KDM4EMAPTHSD17B10SMN1; SMN2LMNA | |
| SCHEMBL6290024 | 0.75 | ALDH1A1 (0.48) | KDM4EMEN1MAPTKMT2AHPGD | |
| SCHEMBL6288516 | 0.73 | S1PR2 (0.39) | KDM4EMEN1MAPTKMT2AHPGD | |
| SCHEMBL10989292 | 0.73 | MEN1 (0.53) | KDM4EMEN1MAPTKMT2AGRIN1 | |
| SCHEMBL10375330 | 0.72 | KDM4E (0.58) | KDM4EMEN1MAPTKMT2AHPGD | |
| SCHEMBL6288151 | 0.72 | KDM4E (0.40) | KDM4EMEN1MAPTKMT2AHSD17B10 | |
| SCHEMBL1085058 | 0.71 | MAPT (0.58) | KDM4EMEN1MAPTKMT2AHPGD | |
| SCHEMBL2493738 | 0.71 | MAPT (0.65) | KDM4EMEN1MAPTKMT2AHPGD | |
| SCHEMBL14282096 | 0.70 | PDE4B (0.43) | KDM4EMAPTKMT2AHSD17B10SMN1; SMN2 | |
| SCHEMBL2373420 | 0.70 | KDM4E (0.49) | KDM4EMEN1MAPTKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6734190-B2 | REGULATION OF T CELL RESPONSES FOR IMMUNOSUPPRESION | WYETH | 2004-05-11 | — | — | US | disclosed |
| US-20040024008-A1 | Dihydrodipyrazolopyridinylbenzamide and -sulfonamide inhibitors of B7-1 | WYETH | 2004-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040024008-A1 | Dihydrodipyrazolopyridinylbenzamide and -sulfonamide inhibitors of B7-1 | CD274, PDCD1, VCAM1 | KDM4E 2182/4885MEN1 2790/4885MAPT 4229/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.