Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 9/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 8/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 1/20 | 0.44 |
| ▸ | NQO1 | P15559 | 1/20 | 0.43 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15772575 | 0.89 | MTNR1A (0.50) | MAPK1MTNR1AMTNR1BSLC6A2SLC6A4 | |
| SCHEMBL15773033 | 0.86 | MTNR1A (0.50) | MAPK1MTNR1AMTNR1BSLC6A2SLC6A4 | |
| SCHEMBL15772597 | 0.83 | MTNR1A (0.49) | MTNR1ANQO1SMN1; SMN2MAPT | |
| SCHEMBL20460323 | 0.81 | DHFR (0.50) | MTNR1AMTNR1BPPARG | |
| SCHEMBL30088510 | 0.80 | CYP1A2 (0.57) | MTNR1ANQO1SMN1; SMN2MAPT | |
| SCHEMBL443625 | 0.80 | CYP1A2 (0.57) | MTNR1ANQO1SMN1; SMN2MAPT | |
| SCHEMBL10604096 | 0.80 | KCNA3 (0.54) | MTNR1ASLC6A4HTR1AHTR1DHTR1B | |
| SCHEMBL7562100 | 0.78 | NQO1 (0.37) | MAPK1MTNR1AMTNR1BHTR1AHTR1D | |
| SCHEMBL12968019 | 0.77 | HTR1B (0.51) | MTNR1AMTNR1BHTR1DHTR1BKCNA3 | |
| SCHEMBL28792251 | 0.77 | MTNR1A (0.56) | MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2605658-A1 | SPIROXAZOLIDINONE COMPOUNDS | Merck Sharp & Dohme Corp. (US) | 2013-06-26 | — | — | EP | disclosed |
| WO-2012024183-A1 | SPIROXAZOLIDINONE COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2012-02-23 | — | — | WO | disclosed |