Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 7/20 | 0.41 |
| ▸ | CA1 | P00915 | 4/20 | 0.48 |
| ▸ | CA2 | P00918 | 4/20 | 0.48 |
| ▸ | CA7 | P43166 | 3/20 | 0.48 |
| ▸ | CA9 | Q16790 | 3/20 | 0.48 |
| ▸ | CA12 | O43570 | 2/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.48 |
| ▸ | CA4 | P22748 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | BCHE | P06276 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4207957 | 0.98 | CA1 (0.50) | CA1CA2CA7CA9CA12 | |
| SCHEMBL16754277 | 0.90 | CA1 (0.43) | CA1CA2CA7CA9CA12 | |
| Hydrochloric Acid SCHEMBL8124009 | 0.76 | L3MBTL1 (0.46) | CA1CA2CA7CA9CA12 | |
| SCHEMBL17996981 | 0.76 | ACHE (0.39) | CA1CA2CA7CA9CA12 | |
| SCHEMBL9032017 | 0.74 | CYP1A1 (0.39) | CA1CA2CA7CA9CA12 | |
| SCHEMBL19607289 | 0.73 | ACHE (0.43) | CA1CA2CA7CA9CA12 | |
| SCHEMBL11235009 | 0.71 | IDO1 (0.40) | CA1CA2CA7CA9CA12 | |
| SCHEMBL19607241 | 0.71 | ACHE (0.48) | CA1CA2CA7CA9CA12 | |
| 1,2-Dimethoxybenzene SCHEMBL27452731 | 0.71 | CA1 (0.93) | CA1CA2CA7CA9CA12 | |
| Hydrochloric Acid SCHEMBL9027412 | 0.70 | MKNK1 (0.49) | CA1CA2CA7CA9CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6790588-B2 | Imagable articles and compositions therefor | KODAK POLYCHROME GRAPHICS LLC | 2004-09-14 | — | — | US | disclosed |
| US-20040048186-A1 | Imagable articles and compositions therefor | KODAK POLYCHROME GRAPHICS LLC. | 2004-03-11 | — | — | US | disclosed |