Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A1 | P22736 | 1/20 | 0.66 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.66 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.66 |
| ▸ | CES2 | O00748 | 2/20 | 0.59 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.49 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6703585 | 1.00 | NR4A1 (0.66) | NR4A1NR4A2NR4A3CES2SRD5A2 | |
| SCHEMBL7961951 | 0.86 | CES2 (0.57) | NR4A1NR4A2NR4A3CES2SRD5A2 | |
| SCHEMBL7961946 | 0.86 | CES2 (0.57) | NR4A1NR4A2NR4A3CES2SRD5A2 | |
| SCHEMBL7961170 | 0.83 | NPSR1 (0.55) | CES2SRD5A2ALDH1A1MEN1KMT2A | |
| SCHEMBL7961166 | 0.83 | NPSR1 (0.55) | CES2SRD5A2ALDH1A1MEN1KMT2A | |
| SCHEMBL8956626 | 0.82 | CES2 (0.61) | CES2SRD5A2ALDH1A1MEN1KMT2A | |
| SCHEMBL8956617 | 0.82 | CES2 (0.61) | CES2SRD5A2ALDH1A1MEN1KMT2A | |
| SCHEMBL19592309 | 0.81 | CES2 (0.58) | CES2SRD5A2ALDH1A1MEN1KMT2A | |
| SCHEMBL20806278 | 0.80 | CES2 (0.56) | CES2SRD5A2ALDH1A1MEN1KMT2A | |
| SCHEMBL4021645 | 0.80 | NR4A1 (1.00) | NR4A1NR4A2NR4A3CES2SRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040006081-A1 | Pharmaceutically active piperidine derivatives, in particular as modulators of chemokine receptor activity | ASTRAZENECA AB (SE) | 2004-01-08 | — | — | US | disclosed |
| EP-1289957-A1 | PHARMACEUTICALLY ACTIVE PIPERIDINE DERIVATIVES, IN PARTICULAR AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | AstraZeneca AB (SE) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001087839-A1 | PHARMACEUTICALLY ACTIVE PIPERIDINE DERIVATIVES, IN PARTICULAR AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA AB (SE) | 2001-11-22 | — | — | WO | disclosed |
| US-6281209-B1 | Fungicidal alkoximinomethyldioxazine derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 2001-08-28 | — | — | US | disclosed |
| EP-0973728-A1 | ACRYLIC ACID PHENYLESTER DERIVATIVES | BAYER AG (DE) | 2000-01-26 | — | — | EP | disclosed |
| EP-0970061-A1 | FUNGICIDAL ALKOXIMINOMETHYLDIOXAZINE DERIVATIVES | BAYER AG (DE) | 2000-01-12 | — | — | EP | disclosed |
| WO-1998040365-A1 | FUNGICIDAL ALKOXIMINOMETHYLDIOXAZINE DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 1998-09-17 | — | — | WO | disclosed |
| WO-1998040351-A1 | ACRYLIC ACID PHENYLESTER DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 1998-09-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040006081-A1 | Pharmaceutically active piperidine derivatives, in particular as modulators of chemokine receptor activity | CCR5, CCR2, CCR1 | NR4A1 578/4885NR4A2 699/4885NR4A3 558/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.