SCHEMBL6704259

SCHEMBL6704259

O=C1CC(c2ccccc2)(C2(c3ccccc3)CC(=O)c3ccccc3O2)Oc2ccccc21

nearest known ligand 0.47

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 1/20 0.47
ATM Q13315 1/20 0.46
CFTR P13569 1/20 0.44
GOPC Q9HD26 1/20 0.44
MAOB P27338 2/20 0.41
KDM4E B2RXH2 1/20 0.41
ADORA3 P0DMS8 1/20 0.41
AR P10275 1/20 0.41
CYP19A1 P11511 1/20 0.41
HSD17B10 Q99714 1/20 0.41
EPHX2 P34913 2/20 0.38
CYP2C9 P11712 1/20 0.38
ALDH1A1 P00352 1/20 0.38
ADRA1D P25100 2/20 0.38
ADRA1A P35348 2/20 0.38
ADRA1B P35368 2/20 0.38
HSD11B1 P28845 1/20 0.36
PKM P14618 1/20 0.36
TSHR P16473 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL753626 0.83 SIGMAR1 (0.45) SIGMAR1ATMCFTRGOPCMAOB
SCHEMBL2022537 0.83 SIGMAR1 (0.45) SIGMAR1ATMCFTRGOPCMAOB
SCHEMBL11256545 0.82 SIGMAR1 (0.47) SIGMAR1ATMCFTRGOPCMAOB
SCHEMBL29818629 0.82 SIGMAR1 (0.47) SIGMAR1ATMCFTRGOPCMAOB
Dextrose SCHEMBL7451779 0.80 SIGMAR1 (0.37) SIGMAR1ATMALDH1A1
SCHEMBL31190168 0.79 SIGMAR1 (0.45) SIGMAR1ATMCFTRGOPCMAOB
SCHEMBL9278695 0.79 ATM (0.47) SIGMAR1ATMCFTRGOPCMAOB
SCHEMBL1534682 0.79 SIGMAR1 (0.45) SIGMAR1ATMCFTRGOPCMAOB
SCHEMBL927371 0.79 SIGMAR1 (0.45) SIGMAR1ATMCFTRGOPCMAOB
SCHEMBL2477934 0.79 SIGMAR1 (0.45) SIGMAR1ATMCFTRGOPCMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0039265-B1 MEDICINE CONTAINING A BIFLAVANONE COMPOUND SCIENCE UNION ET Cie SOCIETE FRANCAISE DE RECHERCHE MEDICALE (FR) 1983-07-06 EP claimed
EP-0039265-A1 Medicine containing a biflavanone compound SCIENCE UNION ET Cie SOCIETE FRANCAISE DE RECHERCHE MEDICALE (FR) 1981-11-04 EP claimed
US-11918615-B2 Anti-inflammatory botanical extract INNOPHOS, LLC (US) 2024-03-05 US disclosed
US-11903989-B2 Botanical modulator of metabolic disorders INNOPHOS, LLC (US) 2024-02-20 US disclosed
US-20220031788-A1 Anti-Inflammatory Botanical Extract INNOPHOS, LLC (US) 2022-02-03 US disclosed
US-20220023367-A1 Botanical Antioxidants INNOPHOS, LLC (US) 2022-01-27 US disclosed
US-20210401917-A1 Botanical Modulator of Metabolic Disorders INNOPHOS, LLC (US) 2021-12-30 US disclosed
US-11147849-B2 Botanical modulator of metabolic disorders INNOPHOS, LLC (US) 2021-10-19 US disclosed
US-11141446-B2 Anti-inflammatory botanical extract INNOPHOS, LLC (US) 2021-10-12 US disclosed
US-11141445-B2 Botanical antioxidants INNOPHOS, LLC (US) 2021-10-12 US disclosed
US-11045669-B2 Hydroalcoholic extract of Schinus molle, cosmetic compositions comprising the same and cosmetic uses thereof ISP INVESTMENTS LLC (US) 2021-06-29 US disclosed
WO-1998046238-A1 BIFLAVINOIDS AND DERIVATIVES THEREOF AS ANTIVIRAL AGENTS, ALONE OR IN COMBINATION WITH AT LEAST ONE KNOWN ANTIVIRAL AGENT MEDICHEM RESEARCH, INC. (US) 1998-10-22 WO disclosed
US-5773462-A INFLUENZA THERAPY MEDICHEM RESEARCH, INC. (US) 1998-06-30 US disclosed
EP-0833631-A1 BIFLAVANOIDS AND DERIVATIVES THEREOF AS ANTIVIRAL AGENTS MEDICHEM RESEARCH, INC. (US) 1998-04-08 EP disclosed
WO-1997000679-A1 BIFLAVANOIDS AND DERIVATIVES THEREOF AS ANTIVIRAL AGENTS MEDICHEM RESEARCH, INC. (US) 1997-01-09 WO disclosed
EP-0039265-B1 MEDICINE CONTAINING A BIFLAVANONE COMPOUND SCIENCE UNION ET Cie SOCIETE FRANCAISE DE RECHERCHE MEDICALE (FR) 1983-07-06 EP disclosed
EP-0039265-B1 MEDICINE CONTAINING A BIFLAVANONE COMPOUND SCIENCE UNION ET Cie SOCIETE FRANCAISE DE RECHERCHE MEDICALE (FR) 1983-07-06 EP disclosed
EP-0039265-A1 Medicine containing a biflavanone compound SCIENCE UNION ET Cie SOCIETE FRANCAISE DE RECHERCHE MEDICALE (FR) 1981-11-04 EP disclosed
EP-0039265-A1 Medicine containing a biflavanone compound SCIENCE UNION ET Cie SOCIETE FRANCAISE DE RECHERCHE MEDICALE (FR) 1981-11-04 EP disclosed
EP-0039265-A1 Medicine containing a biflavanone compound SCIENCE UNION ET Cie SOCIETE FRANCAISE DE RECHERCHE MEDICALE (FR) 1981-11-04 EP disclosed