SCHEMBL670434

SCHEMBL670434

O=[N+]([O-])c1ccc(N2CCC(CO)CC2)nc1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 7/20 0.69
ALDH1A1 P00352 4/20 0.63
LMNA P02545 1/20 0.63
ALOX12 P18054 1/20 0.63
NPSR1 Q6W5P4 1/20 0.63
CYP1A2 P05177 1/20 0.60
CYP2C9 P11712 1/20 0.60
HPGD P15428 1/20 0.60
L3MBTL1 Q9Y468 2/20 0.60
POLB P06746 1/20 0.60
MEN1 O00255 5/20 0.58
KMT2A Q03164 5/20 0.58
ATM Q13315 1/20 0.58
MAPK1 P28482 2/20 0.55
NPY2R P49146 1/20 0.55
NPBWR1 P48145 1/20 0.54
MCHR1 Q99705 1/20 0.54
CRBN Q96SW2 2/20 0.50
KDM4E B2RXH2 1/20 0.47
PANK3 Q9H999 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23117813 0.90 MAPT (0.66) MAPTALDH1A1LMNAALOX12NPSR1
SCHEMBL29772018 0.86 MAPT (0.60) MAPTALDH1A1LMNAALOX12NPSR1
SCHEMBL3542851 0.86 MAPT (0.64) MAPTALDH1A1LMNAALOX12NPSR1
SCHEMBL3542849 0.86 MAPT (0.64) MAPTALDH1A1LMNAALOX12NPSR1
SCHEMBL852804 0.85 MAPT (0.74) MAPTALDH1A1LMNAALOX12NPSR1
SCHEMBL23117860 0.84 MAPT (0.66) MAPTALDH1A1LMNAALOX12NPSR1
SCHEMBL29772095 0.83 MAPT (0.60) MAPTALDH1A1LMNAALOX12NPSR1
SCHEMBL596528 0.82 MAPT (0.62) MAPTALDH1A1LMNAALOX12NPSR1
SCHEMBL6949058 0.82 MAPT (0.74) MAPTALDH1A1LMNAALOX12NPSR1
SCHEMBL10113807 0.82 MAPT (0.45) MAPTALDH1A1LMNAALOX12NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12570662-B2 Substituted pyrrolo[1,2-b]pyridazines as bifunctional degraders of interleukin-1 receptor-associated kinases NURIX THERAPEUTICS, INC. (US) 2026-03-10 US disclosed
US-20250082762-A1 NOVEL BIFUNCTIONAL HETEROCYCLIC COMPOUND HAVING BTK DEGRADATION FUNCTION VIA UBIQUITIN PROTEASOME PATHWAY, AND USE THEREOF KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2025-03-13 US disclosed
US-20250073341-A1 BIFUNCTIONAL HETEROCYCLIC COMPOUND HAVING BTK DEGRADATION FUNCTION VIA UBIQUITIN PROTEASOME PATHWAY, AND USE THEREOF KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2025-03-06 US disclosed
EP-4512402-A2 BIFUNCTIONAL DEGRADERS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES AND THERAPEUTIC USE THEREOF Nurix Therapeutics, Inc. (US) 2025-02-26 EP disclosed
US-20250041429-A1 COMPOUND HAVING BTK PROTEIN DEGRADATION ACTIVITY, AND MEDICAL USES THEREOF UBIX THERAPEUTICS, INC. (KR) 2025-02-06 US disclosed
EP-4367118-B1 BIFUNCTIONAL DEGRADERS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES AND THERAPEUTIC USE THEREOF NURIX THERAPEUTICS INC (US) 2025-01-29 EP disclosed
US-20240417402-A1 SUBSTITUTED PYRROLO[1,2-b]PYRIDAZINES AS BIFUNCTIONAL DEGRADERS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES GILEAD SCIENCES, INC. 2024-12-19 US disclosed
US-12161722-B2 Bifunctional heterocyclic compound having BTK degradation function via ubiquitin proteasome pathway, and use thereof KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2024-12-10 US disclosed
WO-2024227104-A1 BIFUNCTIONAL COMPOUNDS FOR DEGRADING BRAF VIA UBIQUITIN PROTEOSOME PATHWAY NURIX THERAPEUTICS, INC. (US) 2024-10-31 WO disclosed
EP-4428130-A1 COMPOUND HAVING BTK PROTEIN DEGRADATION ACTIVITY, AND MEDICAL USES THEREOF Ubix Therapeutics, Inc. (KR) 2024-09-11 EP disclosed
US-20120172369-A1 INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE MERCK SHARP & DOHME CORP. 2012-07-05 US disclosed
US-20120172369-A1 INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE MERCK SHARP & DOHME CORP. 2012-07-05 US disclosed
WO-2012024179-A1 SUBSTITUTED AMIDE DERIVATIVES AS DGAT-1 INHIBITORS MERCK SHARP & DOHME CORP. (US) 2012-02-23 WO disclosed
WO-2012024179-A1 SUBSTITUTED AMIDE DERIVATIVES AS DGAT-1 INHIBITORS MERCK SHARP & DOHME CORP. (US) 2012-02-23 WO disclosed
EP-2367598-A2 INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE Schering Corporation (US) 2011-09-28 EP disclosed
US-20110224137-A1 INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE MERCK SHARP & DOHME CORP. 2011-09-15 US disclosed
US-20110224137-A1 INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE MERCK SHARP & DOHME CORP. 2011-09-15 US disclosed
WO-2011031628-A1 INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE SCHERING CORPORATION (US) 2011-03-17 WO disclosed
WO-2010059602-A2 INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE SCHERING CORPORATION (US) 2010-05-27 WO disclosed
WO-2010059602-A2 INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE SCHERING CORPORATION (US) 2010-05-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250073341-A1 BIFUNCTIONAL HETEROCYCLIC COMPOUND HAVING BTK DEGRADATION FUNCTION VIA UBIQUITIN PROTEASOME PATHWAY, AND USE THEREOF BTK, XIAP, SYK MAPT 2323/4885ALDH1A1 4363/4885LMNA 4647/4885
US-12570662-B2 Substituted pyrrolo[1,2-b]pyridazines as bifunctional degraders of interleukin-1 receptor-associated kinases IRAK1, IRAK2, IRAK4 MAPT 900/4885ALDH1A1 1750/4885LMNA 2312/4885
US-20120172369-A1 INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE DGAT2, DGAT1, LCAT MAPT 2822/4885ALDH1A1 781/4885LMNA 3849/4885
US-20250082762-A1 NOVEL BIFUNCTIONAL HETEROCYCLIC COMPOUND HAVING BTK DEGRADATION FUNCTION VIA UBIQUITIN PROTEASOME PATHWAY, AND USE THEREOF BTK, XIAP, UBE3C MAPT 2100/4885ALDH1A1 4435/4885LMNA 4677/4885
US-20240417402-A1 SUBSTITUTED PYRROLO[1,2-b]PYRIDAZINES AS BIFUNCTIONAL DEGRADERS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES IRAK1, IRAK2, IRAK4 MAPT 1909/4885ALDH1A1 1402/4885LMNA 4015/4885
US-12161722-B2 Bifunctional heterocyclic compound having BTK degradation function via ubiquitin proteasome pathway, and use thereof BTK, XIAP, SYK MAPT 2323/4885ALDH1A1 4363/4885LMNA 4647/4885
US-20110224137-A1 INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE DGAT2, DGAT1, LCAT MAPT 2416/4885ALDH1A1 670/4885LMNA 3831/4885
US-20250041429-A1 COMPOUND HAVING BTK PROTEIN DEGRADATION ACTIVITY, AND MEDICAL USES THEREOF BTK, LYN, SYK MAPT 3790/4885ALDH1A1 4704/4885LMNA 4396/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.