Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 11/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4846178 | 0.82 | DHFR (0.82) | DHFR | |
| SCHEMBL4845865 | 0.82 | DHFR (0.63) | DHFR | |
| SCHEMBL4847876 | 0.82 | DHFR (0.64) | DHFR | |
| SCHEMBL4838316 | 0.76 | DHFR (0.71) | DHFR | |
| SCHEMBL4841496 | 0.74 | DHFR (0.61) | DHFR | |
| SCHEMBL6703985 | 0.74 | DHFR (0.67) | DHFR | |
| SCHEMBL29913394 | 0.72 | DHFR (0.64) | DHFR | |
| SCHEMBL6280112 | 0.69 | GHSR (0.77) | DHFR | |
| SCHEMBL31404403 | 0.67 | LTA4H (0.47) | — | |
| SCHEMBL14544256 | 0.66 | FFAR1 (0.68) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040180913-A1 | Antimalarial pyrimidine derivatives and methods of making and using them | NATIONAL SCIENCE AND TECHNOLOGY DEVELOPMENT AGENCY (TH) | 2004-09-16 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040180913-A1 | Antimalarial pyrimidine derivatives and methods of making and using them | DHFR, TYMP, TYMS | DHFR 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.