Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 14/20 | 0.79 |
| ▸ | PAK4 | O96013 | 2/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6684201 | 0.88 | TGFBR1 (1.00) | TGFBR1ROCK2MAPK14 | |
| SCHEMBL30814808 | 0.88 | TGFBR1 (1.00) | TGFBR1ROCK2MAPK14 | |
| SCHEMBL3592877 | 0.83 | TGFBR1 (0.54) | TGFBR1PAK4ROCK2 | |
| SCHEMBL3590264 | 0.81 | PAK4 (0.53) | TGFBR1PAK4ROCK2 | |
| SCHEMBL3588932 | 0.80 | ROCK2 (0.63) | TGFBR1ROCK2 | |
| SCHEMBL3578380 | 0.80 | PAK4 (0.52) | TGFBR1PAK4ROCK2 | |
| SCHEMBL3578657 | 0.79 | TNIK (0.53) | TGFBR1PAK4ROCK2 | |
| SCHEMBL5736843 | 0.77 | ROCK2 (0.56) | TGFBR1PAK4ROCK2MAPK14 | |
| SCHEMBL3583464 | 0.77 | ROCK2 (0.58) | TGFBR1PAK4ROCK2 | |
| Hydrochloric Acid SCHEMBL3581146 | 0.76 | ROCK2 (0.56) | TGFBR1PAK4ROCK2MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004065392-A1 | CONDENSED PYRIDINES AND PYRIMIDINES AND THEIR USE AS ALK-5 RECEPTOR LIGANDS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-08-05 | — | — | WO | disclosed |