Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | AR | P10275 | 12/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | SHBG | P04278 | 1/20 | 0.51 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.47 |
| ▸ | PGR | P06401 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mexrenoate SCHEMBL19874044 | 1.00 | TDP1 (0.59) | TDP1MEN1KMT2AARALDH1A1 | |
| Mexrenoate SCHEMBL6705061 | 1.00 | TDP1 (0.59) | TDP1MEN1KMT2AARALDH1A1 | |
| Mexrenoate SCHEMBL11692751 | 1.00 | TDP1 (0.59) | TDP1MEN1KMT2AARALDH1A1 | |
| SCHEMBL11597879 | 0.92 | TDP1 (0.57) | TDP1MEN1KMT2AARALDH1A1 | |
| SCHEMBL11690830 | 0.92 | TDP1 (0.59) | TDP1MEN1KMT2AARALDH1A1 | |
| SCHEMBL11597885 | 0.92 | TDP1 (0.57) | TDP1MEN1KMT2AARALDH1A1 | |
| SCHEMBL11690842 | 0.92 | TDP1 (0.59) | TDP1MEN1KMT2AARALDH1A1 | |
| SCHEMBL11597202 | 0.92 | TDP1 (0.57) | TDP1MEN1KMT2AARALDH1A1 | |
| Mexrenoate SCHEMBL122938 | 0.90 | TDP1 (0.71) | TDP1MEN1KMT2AARALDH1A1 | |
| SCHEMBL5179803 | 0.89 | MEN1 (0.55) | TDP1MEN1KMT2AARALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040242552-A1 | New use of antimineralocorticoid compounds against narcotic withdrawal syndrome | AVENTIS PHARMA S.A. | 2004-12-02 | — | — | US | claimed |
| EP-0863760-B1 | USE OF ANTIMINERALOCORTICOID COMPOUNDS AGAINST DRUG WITHDRAWAL SYNDROME | AVENTIS PHARMA SA (FR) | 2001-12-05 | — | — | EP | claimed |
| US-4053580-A | POLYSILOXANE, POLYOXYETHYLENE GLYCOL | G. D. SEARLE & CO. (US) | 1977-10-11 | — | — | US | claimed |
| US-3946106-A | POLYSILOXANES | G. D. SEARLE & CO. (US) | 1976-03-23 | — | — | US | claimed |
| US-20040242552-A1 | New use of antimineralocorticoid compounds against narcotic withdrawal syndrome | AVENTIS PHARMA S.A. | 2004-12-02 | — | — | US | disclosed |
| US-6759399-B1 | USING SUCH AS GAMMA-LACTONE OF 10-ETHYNYL-17-HYDROXY-3-OXO-19-NOR-17-PREGNA-4,9(11)-DIENE-21-CARBOXYLIC ACID | AVENTIS PHARMA S.A. (FR) | 2004-07-06 | — | — | US | disclosed |
| US-6147066-A | Use of antimineralocorticoid compounds against drug withdrawal syndrome | Roussel, Hoechst Marion (FR) | 2000-11-14 | — | — | US | disclosed |
| US-4069219-A | 7ξ-(Alkoxycarbonyl)-6ξ-alkyl/halo-17-hydroxy-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactones and corresponding 21-carboxylic acids, their salts, and esters | G. D. SEARLE & CO. (US) | 1978-01-17 | — | — | US | disclosed |
| US-4053580-A | POLYSILOXANE, POLYOXYETHYLENE GLYCOL | G. D. SEARLE & CO. (US) | 1977-10-11 | — | — | US | disclosed |
| US-3992518-A | CROSSLINKING SILICONE POLYMERS | G. D. SEARLE & CO. (US) | 1976-11-16 | — | — | US | disclosed |
| US-3972871-A | 6β,17-Dihydroxy-7α-(lower alkoxy)carbonyl-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactones and congeners | G. D. SEARLE & CO. (US) | 1976-08-03 | — | — | US | disclosed |
| US-3946106-A | POLYSILOXANES | G. D. SEARLE & CO. (US) | 1976-03-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040242552-A1 | New use of antimineralocorticoid compounds against narcotic withdrawal syndrome | OPRM1, PNMT, SLC6A11 | TDP1 2581/4885MEN1 1425/4885KMT2A 1784/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.