Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL669776 | 0.85 | NPC1 (0.43) | ALDH1A1KMT2ANPC1RAB9ATAS2R8 | |
| SCHEMBL2393208 | 0.82 | MAPT (0.68) | MAPTALDH1A1NPBWR1MCHR1L3MBTL1 | |
| SCHEMBL2391556 | 0.78 | MAPT (0.50) | MAPTALDH1A1NPBWR1MCHR1L3MBTL1 | |
| SCHEMBL10113257 | 0.78 | DGAT1 (0.54) | MAPTALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL672428 | 0.76 | MAPT (0.47) | MAPTALDH1A1NPBWR1MCHR1L3MBTL1 | |
| SCHEMBL672427 | 0.76 | MAPT (0.47) | MAPTALDH1A1NPBWR1MCHR1L3MBTL1 | |
| SCHEMBL12503559 | 0.74 | CYP2D6 (0.43) | ALDH1A1L3MBTL1KMT2ATAS2R8ROCK2 | |
| SCHEMBL669645 | 0.73 | DGAT1 (0.54) | MAPTALDH1A1L3MBTL1LMNAKMT2A | |
| SCHEMBL31744055 | 0.73 | MAPT (0.45) | MAPTLMNAKMT2AMEN1RAB9A | |
| SCHEMBL671044 | 0.73 | LOXL2 (0.48) | MAPTALDH1A1L3MBTL1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012024179-A1 | SUBSTITUTED AMIDE DERIVATIVES AS DGAT-1 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-02-23 | — | — | WO | disclosed |
| WO-2012024179-A1 | SUBSTITUTED AMIDE DERIVATIVES AS DGAT-1 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-02-23 | — | — | WO | disclosed |