Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.47 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10113453 | 0.86 | HDAC1 (0.53) | LOXL2MAPTL3MBTL1CYP4F2CYP4A11 | |
| SCHEMBL5177505 | 0.85 | HDAC1 (0.50) | LOXL2MAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL675320 | 0.83 | LOXL2 (0.50) | LOXL2MAPTL3MBTL1CYP4F2CYP4A11 | |
| SCHEMBL6630922 | 0.82 | MEN1 (0.61) | LOXL2MAPTL3MBTL1CYP4F2CYP4A11 | |
| SCHEMBL22346843 | 0.81 | LOXL2 (0.52) | LOXL2MAPTL3MBTL1CYP4F2CYP4A11 | |
| SCHEMBL4108176 | 0.79 | KMT2A (0.54) | L3MBTL1ALDH1A1KMT2ASMN1; SMN2POLB | |
| SCHEMBL6980504 | 0.79 | ABCB1 (0.42) | ROCK2ROCK1MEN1ALDH1A1KMT2A | |
| SCHEMBL671067 | 0.79 | CHRM3 (0.53) | LOXL2MAPTL3MBTL1CYP4F2CYP4A11 | |
| SCHEMBL3903191 | 0.76 | FAAH (0.53) | L3MBTL1ROCK2ROCK1 | |
| SCHEMBL31773 | 0.76 | LOXL2 (0.52) | LOXL2MAPTL3MBTL1CYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012024179-A1 | SUBSTITUTED AMIDE DERIVATIVES AS DGAT-1 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-02-23 | — | — | WO | disclosed |