Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 12/20 | 0.49 |
| ▸ | PSEN2 | P49810 | 12/20 | 0.49 |
| ▸ | APH1B | Q8WW43 | 12/20 | 0.49 |
| ▸ | NCSTN | Q92542 | 12/20 | 0.49 |
| ▸ | APH1A | Q96BI3 | 12/20 | 0.49 |
| ▸ | PSENEN | Q9NZ42 | 12/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.47 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6701989 | 0.76 | KDM1A (0.53) | HRH3CYP2D6MAOAMAOBHRH1 | |
| Hydrochloric Acid SCHEMBL6697715 | 0.75 | PSEN1 (0.66) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5074380 | 0.74 | PSEN1 (0.64) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5071689 | 0.73 | PSEN1 (0.66) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4045668 | 0.71 | MAOA (0.52) | HRH3CYP2D6MAOAMAOBHRH1 | |
| SCHEMBL14263757 | 0.71 | MAOA (0.52) | HRH3CYP2D6MAOAMAOBHRH1 | |
| SCHEMBL5143709 | 0.70 | GRIN2B (0.54) | HRH3CYP2D6MAOAMAOBHRH1 | |
| SCHEMBL12471199 | 0.70 | HRH3 (0.51) | HRH3CYP2D6MAOAMAOBHRH1 | |
| SCHEMBL5074366 | 0.69 | PSEN1 (0.73) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL12472053 | 0.69 | FAAH (0.59) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040049038-A1 | Sulfamides as gamma-secretase inhibitors | MERCK SHARP & DOHME (UK) LIMITED (GB) | 2004-03-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040049038-A1 | Sulfamides as gamma-secretase inhibitors | BACE1, BACE2, PSEN1 | PSEN1 3/4885PSEN2 5/4885APH1B 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.