Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.54 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.53 |
| ▸ | MC4R | P32245 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | IGF1R | P08069 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3595876 | 0.86 | EPHX1 (0.57) | SIGMAR1SLC6A4SLC6A3EPHX1 | |
| SCHEMBL3594490 | 0.86 | EPHX1 (0.57) | SIGMAR1SLC6A4SLC6A3EPHX1 | |
| SCHEMBL7369953 | 0.86 | EPHX1 (0.57) | SIGMAR1SLC6A4SLC6A3EPHX1 | |
| SCHEMBL8267549 | 0.85 | SLC6A4 (0.56) | SIGMAR1SLC6A4SLC6A3EPHX1MC4R | |
| SCHEMBL7216040 | 0.85 | SLC6A4 (0.56) | SIGMAR1SLC6A4SLC6A3EPHX1MC4R | |
| SCHEMBL1619274 | 0.85 | SLC6A4 (0.56) | SIGMAR1SLC6A4SLC6A3EPHX1MC4R | |
| Hydrochloric Acid SCHEMBL4350813 | 0.84 | EPHX1 (0.55) | SIGMAR1KDM4ESLC6A4SLC6A3EPHX1 | |
| SCHEMBL11991373 | 0.84 | EPHX1 (0.55) | SIGMAR1SLC6A4SLC6A3EPHX1 | |
| SCHEMBL13405058 | 0.84 | EPHX1 (0.55) | SIGMAR1SLC6A4SLC6A3EPHX1 | |
| Hydrochloric Acid SCHEMBL6007251 | 0.84 | EPHX1 (0.55) | SIGMAR1KDM4ESLC6A4SLC6A3EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6831084-B1 | Agonism and antagonism; neuroprotection; strokes including thromboembolic and focal, global or tranient ischemic attack | WYETH | 2004-12-14 | — | — | US | disclosed |
| US-6828324-B2 | Provide neuroprotection and prevent, inhibit or limit processes of neurodegeneration in mammals | WYETH | 2004-12-07 | — | — | US | disclosed |
| US-20040162430-A1 | Branched adamantyl and noradamantyl aryl-and aralkylpiperazines with serotonin 5-HT 1A activity | WYETH (US) | 2004-08-19 | — | — | US | disclosed |
| EP-1276731-A2 | BRANCHED ADAMANTYL AND NORADAMANTYL ARYL- AND ARALKYLPIPERAZINES WITH SEROTONIN 5-HT 1A ACTIVITY | Wyeth (US) | 2003-01-22 | — | — | EP | disclosed |
| WO-2001034586-A2 | BRANCHED ADAMANTYL AND NORADAMANTYL ARYL- AND ARALKYLPIPERAZINES WITH SEROTONIN 5-HT1A ACTIVITY | WYETH (US) | 2001-05-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040162430-A1 | Branched adamantyl and noradamantyl aryl-and aralkylpiperazines with serotonin 5-HT 1A activity | HTR1A, HTR5A, PARL | SIGMAR1 760/4885KDM4E 4270/4885SLC6A4 193/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.