Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN3A | Q9NY46 | 4/20 | 0.50 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.49 |
| ▸ | NAMPT | P43490 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.40 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4833761 | 1.00 | SCN3A (0.50) | SCN3ADEGS1NAMPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL4831088 | 1.00 | SCN3A (0.50) | SCN3ADEGS1NAMPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL4835303 | 0.81 | RAB9A (0.43) | SMN1; SMN2LMNAHTTNPC1RAB9A | |
| SCHEMBL4831067 | 0.75 | DDX3X (0.44) | SMN1; SMN2ALDH1A1GAAHTTNPC1 | |
| SCHEMBL4825817 | 0.73 | PKM (0.45) | SMN1; SMN2MEN1KMT2A | |
| SCHEMBL4825661 | 0.71 | MAPT (0.48) | SMN1; SMN2ALDH1A1LMNAGAAHTT | |
| SCHEMBL4831085 | 0.70 | SCN3A (0.51) | SCN3ADEGS1NAMPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL4833753 | 0.70 | SCN3A (0.51) | SCN3ADEGS1NAMPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL4826357 | 0.70 | CFTR (0.38) | LMNAHDAC1 | |
| SCHEMBL15706299 | 0.70 | DEGS1 (0.82) | SCN3ADEGS1NAMPTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1425284-A2 | FURO- AND THIENOPYRIMIDINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-06-09 | — | — | EP | disclosed |
| WO-2003022852-A2 | FURO-AND THIENOPYRIMIDINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-03-20 | — | — | WO | disclosed |