Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.59 |
| ▸ | HTR1A | P08908 | 7/20 | 0.59 |
| ▸ | HTR2A | P28223 | 4/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | DRD4 | P21917 | 6/20 | 0.55 |
| ▸ | DRD3 | P35462 | 5/20 | 0.55 |
| ▸ | HTR6 | P50406 | 3/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6042752 | 0.77 | DRD2 (0.63) | DRD2HTR1AHTR2AHTTDRD4 | |
| SCHEMBL11874262 | 0.77 | HTR6 (0.55) | DRD2HTR1ADRD4HTR6SLC6A4 | |
| SCHEMBL2395932 | 0.76 | DRD4 (0.67) | DRD2HTR1AHTR2AHTTDRD4 | |
| SCHEMBL7543848 | 0.74 | HTR1A (1.00) | DRD2HTR1AHTR2AHTTHTR6 | |
| SCHEMBL2395487 | 0.74 | DRD2 (0.59) | DRD2HTR1AHTR2AHTTDRD4 | |
| SCHEMBL6043002 | 0.74 | DRD2 (0.59) | DRD2HTR1AHTR2AHTTDRD4 | |
| SCHEMBL11784970 | 0.73 | HTR6 (0.65) | DRD2HTR1AHTR2AHTTDRD4 | |
| SCHEMBL6041614 | 0.73 | DRD2 (0.58) | DRD2HTR1AHTR2AHTTDRD4 | |
| SCHEMBL1719798 | 0.73 | DRD2 (0.76) | DRD2HTR1AHTR2AHTTDRD4 | |
| SCHEMBL6585625 | 0.73 | DRD4 (0.63) | DRD2HTR1AHTR2AHTTDRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040077654-A1 | Aryl piperidine and piperazine derivatives as inducers of ldl-receptor expression | SMITHKLINE BEECHAM CORPORATION | 2004-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040077654-A1 | Aryl piperidine and piperazine derivatives as inducers of ldl-receptor expression | LDLR, NR1H2, NCOR1 | DRD2 1008/4885HTR1A 959/4885HTR2A 526/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.