Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11370297 | 0.86 | ALDH1A1 (0.59) | CYP1A2CYP2C19HSD17B10KMT2AALDH1A1 | |
| SCHEMBL7277418 | 0.84 | MRGPRX4 (0.54) | KMT2AMAPTCASP1MRGPRX4ALDH1A1 | |
| SCHEMBL28289914 | 0.84 | KMT2A (0.54) | HSD17B10KMT2AMRGPRX4ALDH1A1L3MBTL1 | |
| SCHEMBL10595010 | 0.84 | HSD17B10 (0.54) | HSD17B10KMT2AMAPTCASP1MRGPRX4 | |
| SCHEMBL11370296 | 0.83 | ALDH1A1 (0.58) | CYP1A2HSD17B10KMT2AMAPTMRGPRX4 | |
| SCHEMBL27493266 | 0.82 | ALDH1A1 (0.53) | HSD17B10KMT2AALDH1A1L3MBTL1MAPK1 | |
| SCHEMBL6708188 | 0.81 | MRGPRX4 (0.45) | CYP1A2CYP2C9CYP2C19HSD17B10KMT2A | |
| SCHEMBL3051266 | 0.81 | ALDH1A1 (0.65) | CYP1A2CYP2C9CYP2C19HSD17B10KMT2A | |
| Adipic Acid SCHEMBL28144622 | 0.81 | ALDH1A1 (0.55) | CYP1A2CYP2C19HSD17B10KMT2AMAPT | |
| SCHEMBL3290432 | 0.80 | HSD17B10 (0.56) | HSD17B10KMT2AMRGPRX4ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392315-A1 | METHODS OF TREATING ALZHEIMER'S DISEASE | Elan Pharmaceuticals, Inc. (US) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002100410-A1 | METHODS OF TREATING ALZHEIMER'S DISEASE | ELAN PHARMACEUTICALS, INC. (US) | 2002-12-19 | — | — | WO | disclosed |
| EP-0831826-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A PROTEINASE INHIBITOR AND A MONOGLYCERIDE | F. HOFFMANN-LA ROCHE AG (CH) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996039142-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A PROTEINASE INHIBITOR AND A MONOGLYCERIDE | F. HOFFMANN-LA ROCHE AG (CH) | 1996-12-12 | — | — | WO | disclosed |