Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7277411 | 0.88 | ALDH1A1 (0.51) | MRGPRX4ALDH1A1L3MBTL1MAPK1KDM4E | |
| SCHEMBL6707308 | 0.84 | TNF (0.46) | ALDH1A1KDM4EHPGDTDP1HSD17B10 | |
| SCHEMBL9439620 | 0.82 | ALDH1A1 (0.55) | MRGPRX4ALDH1A1L3MBTL1MAPK1KDM4E | |
| SCHEMBL6708065 | 0.81 | CYP1A2 (0.51) | MRGPRX4ALDH1A1L3MBTL1MAPK1KDM4E | |
| SCHEMBL7277418 | 0.80 | MRGPRX4 (0.54) | MRGPRX4ALDH1A1L3MBTL1MAPK1KDM4E | |
| SCHEMBL7279601 | 0.78 | ALDH1A1 (0.46) | ALDH1A1L3MBTL1MAPK1KDM4EHPGD | |
| SCHEMBL7277556 | 0.78 | ALDH1A1 (0.49) | ALDH1A1L3MBTL1MAPK1KDM4EHPGD | |
| SCHEMBL3051266 | 0.77 | ALDH1A1 (0.65) | MRGPRX4ALDH1A1L3MBTL1MAPK1KDM4E | |
| SCHEMBL21443106 | 0.74 | CDYL (0.59) | ALDH1A1L3MBTL1MAPK1KDM4ECASP1 | |
| SCHEMBL6707441 | 0.74 | ALDH1A1 (0.45) | ALDH1A1L3MBTL1MAPK1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392315-A1 | METHODS OF TREATING ALZHEIMER'S DISEASE | Elan Pharmaceuticals, Inc. (US) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002100410-A1 | METHODS OF TREATING ALZHEIMER'S DISEASE | ELAN PHARMACEUTICALS, INC. (US) | 2002-12-19 | — | — | WO | disclosed |