Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CPN1 | P15169 | 2/20 | 0.43 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.34 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.34 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6443600 | 1.00 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1CPN1CPB2EPHX2 | |
| SCHEMBL6710934 | 0.78 | ALDH1A1 (0.42) | SMN1; SMN2ALDH1A1EPHX2TSHRLMNA | |
| SCHEMBL6710932 | 0.78 | ALDH1A1 (0.42) | SMN1; SMN2ALDH1A1EPHX2TSHRLMNA | |
| SCHEMBL3244080 | 0.77 | CPN1 (0.39) | SMN1; SMN2CPN1CPB2SLC6A1SLC6A11 | |
| SCHEMBL6050056 | 0.75 | CPN1 (0.45) | SMN1; SMN2CPN1CPB2SLC6A1SLC6A11 | |
| SCHEMBL8709229 | 0.75 | ALDH1A1 (0.44) | SMN1; SMN2ALDH1A1TSHRLMNA | |
| SCHEMBL6446438 | 0.75 | ALDH1A1 (0.44) | SMN1; SMN2ALDH1A1TSHRLMNA | |
| SCHEMBL27772357 | 0.72 | CPN1 (0.42) | SMN1; SMN2CPN1CPB2SLC6A1SLC6A11 | |
| SCHEMBL903601 | 0.71 | NPSR1 (0.42) | SMN1; SMN2ALDH1A1TSHRLMNANPSR1 | |
| SCHEMBL1729385 | 0.71 | NPSR1 (0.42) | SMN1; SMN2ALDH1A1TSHRLMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392315-A1 | METHODS OF TREATING ALZHEIMER'S DISEASE | Elan Pharmaceuticals, Inc. (US) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002100410-A1 | METHODS OF TREATING ALZHEIMER'S DISEASE | ELAN PHARMACEUTICALS, INC. (US) | 2002-12-19 | — | — | WO | disclosed |