6-Chloroguanine

6-Chloroguanine

SCHEMBL6711

Nc1nc(Cl)c2nc[nH]c2n1

nearest known ligand 0.52

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 1/20 0.52
CHUK O15111 1/20 0.41
PDPK1 O15530 1/20 0.37
GDA Q9Y2T3 1/20 0.37
CDK2 P24941 1/20 0.35
PNP P00491 1/20 0.34
BRAF P15056 3/20 0.34
PARP1 P09874 2/20 0.33
ALDH1A1 P00352 1/20 0.33
AURKA O14965 1/20 0.33
DAPK3 O43293 1/20 0.33
JAK2 O60674 1/20 0.33
PRKD3 O94806 1/20 0.33
MAP4K4 O95819 1/20 0.33
PAK4 O96013 1/20 0.33
ABL1 P00519 1/20 0.33
CSF1R P07333 1/20 0.33
RET P07949 1/20 0.33
IGF1R P08069 1/20 0.33
MET P08581 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
6-Chloroguanine SCHEMBL29475378 1.00 DPP4 (0.52) DPP4CHUKPDPK1GDACDK2
6-Chloroguanine SCHEMBL9183926 0.98 DPP4 (0.50) DPP4CHUKPDPK1GDACDK2
6-Chloroguanine SCHEMBL9079947 0.98 DPP4 (0.50) DPP4CHUKPDPK1GDACDK2
6-Chloroguanine SCHEMBL8715987 0.98 DPP4 (0.50) DPP4CHUKPDPK1GDACDK2
6-Chloroguanine SCHEMBL18985251 0.88 DPP4 (0.42) DPP4CHUKPDPK1GDA
6-Chloroguanine SCHEMBL17187923 0.83 CDK1 (0.39) DPP4CDK2HSP90AA1HSP90AB1
6-Chloroguanine SCHEMBL9226290 0.82 OR51E2 (0.41) DPP4CHUKHSP90AA1
6-Chloroguanine SCHEMBL27615386 0.82 DPP4 (0.38) DPP4CHUK
SCHEMBL37383 0.79 XDH (0.38) DPP4PARP1ALDH1A1AURKADAPK3
SCHEMBL29354230 0.79 XDH (0.38) DPP4PARP1ALDH1A1AURKADAPK3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 8712 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4696703-A2 NUCLEIC ACID MOLECULES AND USES THEREOF CureVac SE (DE) 2026-02-18 EP claimed
US-20250340868-A1 POLYNUCLEOTIDES ENCODING LINKED ANTIGENS AND USES THEREOF STEMCELL TECHNOLOGIES CANADA INC (CA) 2025-11-06 US claimed
EP-4631970-A2 NUCLEIC ACID MOLECULES AND USES THEREOF CureVac SE (DE) 2025-10-15 EP claimed
EP-4560315-A2 HYBRIDIZING ALL-LNA OLIGONUCLEOTIDES F. Hoffmann-La Roche AG (CH) 2025-05-28 EP claimed
US-20250152737-A1 LIPID NANOPARTICLES COMPRISING VENEZUELAN EQUINE ENCEPHALITIS (VEE) REPLICON AND USES THEREOF STRAND THERAPEUTICS INC. (US) 2025-05-15 US claimed
CN-119977968-A N, N-dibenzyl-N' - (6-chloro-6, 9-dihydro-1H-purin-2-yl) formamidine compound and preparation and application thereof 黄冈鲁班药业股份有限公司 2025-05-13 CN claimed
CN-119977967-A N-methyl-N-benzyl-N' - (6-chloro-6, 9-dihydro-1H-purin-2-yl) formamidine compound and preparation and application thereof 黄冈鲁班药业股份有限公司 2025-05-13 CN claimed
CN-119954809-A Method for separating purine and analogues thereof 杭州中美华东制药有限公司 2025-05-09 CN claimed
CN-119866224-A Polynucleotide encoding a linking antigen and uses thereof 加拿大干细胞技术公司 2025-04-22 CN claimed
EP-3980554-B1 HYBRIDIZING ALL-LNA OLIGONUCLEOTIDES HOFFMANN LA ROCHE (CH) 2025-03-26 EP claimed
EP-0391411-A2 3'-Substituted methyl nucleosides as antiviral agents Bristol-Myers Squibb Company (US) 1990-10-10 EP claimed
EP-0366059-A2 Carbocyclic nucleoside analogs BRISTOL-MYERS SQUIBB COMPANY (US) 1990-05-02 EP claimed
CN-1040978-A New New cyclobutane derivative and preparation method thereof NIPPON KAGAKU SANGYO KK (JP) 1990-04-04 CN claimed
EP-0358154-A2 Novel cyclobutane derivative and process for producing same NIPPON KAYAKU KABUSHIKI KAISHA (JP) 1990-03-14 EP claimed
US-4801710-A Regioselective synthesis of 9-substituted purine acyclonucleoside derivatives MERCK & CO., INC. (US) 1989-01-31 US claimed
EP-0260596-A2 2-Amino-6-alkoxy-purins substituted in position 9, process for their preparation, their use and pharmaceutical compositions containing them HOECHST AKTIENGESELLSCHAFT (DE) 1988-03-23 EP claimed
US-4621140-A Process for preparing 2,6-substituted-9-(1,3-dihydroxy-2-propoxymethyl)-purines and certain derivatives SYNTEX (U.S.A.) INC. (US) 1986-11-04 US claimed
EP-0184473-A1 Regioselective synthesis of 9-substituted purine acyclonucleoside derivatives MERCK & CO. INC. (US) 1986-06-11 EP claimed
EP-0152965-A2 Process for preparing 2,6-substituted-9-(1,3-dihydroxy-2-propoxy-menthyl)-purines and certain derivatives SYNTEX (U.S.A.) INC. (US) 1985-08-28 EP claimed
US-4060616-A VIRICIDE BURROUGHS WELLCOME CO. (US) 1977-11-29 US claimed