Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.50 |
| ▸ | CHUK | O15111 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 3/20 | 0.33 |
| ▸ | PNP | P00491 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 2/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | PAK4 | O96013 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 6-Chloroguanine SCHEMBL6711 | 0.98 | DPP4 (0.52) | DPP4CHUKPDPK1GDACDK2 | |
| 6-Chloroguanine SCHEMBL29475378 | 0.98 | DPP4 (0.52) | DPP4CHUKPDPK1GDACDK2 | |
| 6-Chloroguanine SCHEMBL9079947 | 0.96 | DPP4 (0.50) | DPP4CHUKPDPK1GDACDK2 | |
| 6-Chloroguanine SCHEMBL9183926 | 0.96 | DPP4 (0.50) | DPP4CHUKPDPK1GDACDK2 | |
| 6-Chloroguanine SCHEMBL18985251 | 0.87 | DPP4 (0.42) | DPP4CHUKPDPK1GDA | |
| 6-Chloroguanine SCHEMBL17187923 | 0.82 | CDK1 (0.39) | DPP4CDK2HSP90AA1HSP90AB1 | |
| 6-Chloroguanine SCHEMBL9226290 | 0.81 | OR51E2 (0.41) | DPP4CHUKHSP90AA1 | |
| SCHEMBL37383 | 0.78 | XDH (0.38) | DPP4PARP1AURKADAPK3JAK2 | |
| 2,6-Diaminopurine SCHEMBL24052 | 0.78 | GDA (0.48) | DPP4PDPK1GDACDK2PNP | |
| SCHEMBL29354230 | 0.78 | XDH (0.38) | DPP4PARP1AURKADAPK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5821357-A | REACTING ALPHA-ANOMER ENRICHED 2,2-DIFLUOROCARBOHYDRATE WITH AT LEAST TWO MOLAR EQUIVALENTS OF METAL DERIVATIVE OF NUCLEOBASE IN LOW FREEZING INERT SOLVENT | ELI LILLY AND COMPANY (US) | 1998-10-13 | — | — | US | disclosed |
| EP-0577303-B1 | Stereoselective glycosylation process | LILLY CO ELI (US) | 1997-10-01 | — | — | EP | disclosed |
| EP-0577303-A1 | Stereoselective glycosylation process | ELI LILLY AND COMPANY (US) | 1994-01-05 | — | — | EP | disclosed |