Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | DPP4 | P27487 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | CCR3 | P51677 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13079397 | 0.86 | MAPT (0.57) | MAPTDPP4CYP3A4MCHR1HTR2C | |
| SCHEMBL13045862 | 0.83 | MAPT (0.54) | MAPTDPP4CYP3A4MCHR1HTR2C | |
| SCHEMBL4808090 | 0.80 | SLC6A2 (0.50) | MAPTMCHR1HTR2CMEN1KMT2A | |
| SCHEMBL6234327 | 0.78 | MCHR1 (0.51) | MAPTDPP4CYP3A4MCHR1HTR2C | |
| SCHEMBL9593130 | 0.77 | CCR3 (0.61) | MCHR1CCR3 | |
| SCHEMBL6714388 | 0.77 | MAPT (0.56) | MAPTMCHR1HTR2CFAAHCCR3 | |
| SCHEMBL14044704 | 0.73 | MCHR1 (0.48) | MAPTMCHR1HTR2CMEN1KMT2A | |
| SCHEMBL31010336 | 0.73 | KDM4E (0.51) | MAPTDPP4CYP3A4MCHR1HTR2C | |
| SCHEMBL7058962 | 0.72 | KMT2A (0.51) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL21624810 | 0.71 | PDE10A (0.50) | DPP4CYP3A4MCHR1BACE1PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040034028-A1 | 4-(biphenylcarbonylamino)piperidine derivatives as mtp inhibitors | MERCK PATENT GMBH (DE) | 2004-02-19 | — | — | US | disclosed |
| EP-1335912-A1 | 4-(BIPHENYLCARBONYLAMINO)PIPERIDINE DERIVATIVES AS MTP INHIBITORS | MERCK PATENT GmbH (DE) | 2003-08-20 | — | — | EP | disclosed |
| WO-2002042291-A1 | 4-(BIPHENYLCARBONYLAMINO)PIPERIDINE DERIVATIVES AS MTP INHIBITORS | MERCK PATENT GMBH (DE) | 2002-05-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040034028-A1 | 4-(biphenylcarbonylamino)piperidine derivatives as mtp inhibitors | LIPC, CETP, MTTP | MAPT 4358/4885DPP4 604/4885CYP3A4 241/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.