Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 6/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5764654 | 0.88 | MCHR1 (0.49) | MCHR1FAAHKDM4EMEN1ALDH1A1 | |
| SCHEMBL6254675 | 0.88 | MCHR1 (0.53) | MCHR1MAPTBACE1 | |
| SCHEMBL6233604 | 0.81 | MCHR1 (0.49) | MCHR1MAPTHTR2CFAAHCYP3A4 | |
| SCHEMBL6230997 | 0.81 | MCHR1 (0.49) | MCHR1MAPTHTR2CFAAHCYP3A4 | |
| SCHEMBL2921149 | 0.78 | MAOA (0.48) | MCHR1MAPTHTR2CACHEFAAH | |
| SCHEMBL6711271 | 0.78 | MAPT (0.57) | MCHR1MAPTHTR2CFAAHCYP3A4 | |
| SCHEMBL2926351 | 0.77 | ALDH1A1 (0.47) | MCHR1MAPTHTR2CACHEFAAH | |
| SCHEMBL6234696 | 0.76 | MAPT (0.41) | MCHR1MAPTFAAHKDM4EMEN1 | |
| SCHEMBL2918912 | 0.75 | MCHR1 (0.73) | MCHR1MAPTHTR2CFAAHKDM4E | |
| SCHEMBL13079397 | 0.75 | MAPT (0.57) | MCHR1MAPTHTR2CACHEFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004092181-A9 | HETEROCYCLIC MCHR1 ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2005-01-27 | — | — | WO | disclosed |