Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.34 |
| ▸ | CCR1 | P32246 | 1/20 | 0.34 |
| ▸ | CCR8 | P51685 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | XPO1 | O14980 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 2/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6713575 | 0.87 | HTT (0.50) | HTTHSD17B10IDO1L3MBTL1 | |
| SCHEMBL6718657 | 0.81 | NR4A2 (0.41) | HCAR2IDO1ABCG2NR4A2 | |
| SCHEMBL15346406 | 0.73 | HCAR2 (0.46) | HCAR2ABCG2XPO1ALDH1A1 | |
| SCHEMBL6710925 | 0.70 | NR4A2 (0.40) | HCAR2IDO1ABCG2NR4A2ALDH1A1 | |
| SCHEMBL1519321 | 0.70 | NR4A2 (0.47) | HTTHSD17B10CCR1CCR8L3MBTL1 | |
| SCHEMBL6794325 | 0.70 | HCAR2 (0.40) | HCAR2IDO1KIF11ABCG2XPO1 | |
| SCHEMBL4421954 | 0.67 | HSD17B10 (0.46) | HTTHSD17B10IDO1 | |
| SCHEMBL26859106 | 0.67 | HCAR2 (0.41) | HCAR2HTTHSD17B10IDO1ABCG2 | |
| SCHEMBL3454725 | 0.66 | LMNA (0.41) | HTTHSD17B10L3MBTL1MAOBLMNA | |
| SCHEMBL14189993 | 0.65 | HTT (0.44) | HTTHSD17B10IDO1XPO1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040002498-A1 | Tricyclic compounds useful as HIV reverse transcriptase inhibitors | JOHNSON BARRY L (US) | 2004-01-01 | — | — | US | disclosed |
| US-6593337-B1 | pharmaceutical compositions and diagnostic kits comprising the same, and methods of using the same for treating viral infection or as an assay standard or reagent. | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2003-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040002498-A1 | Tricyclic compounds useful as HIV reverse transcriptase inhibitors | POLRMT, TYMP, POLM | HCAR2 3735/4885HTT 2749/4885HSD17B10 353/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.