Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | XPO1 | O14980 | 1/20 | 0.33 |
| ▸ | CCNC | P24863 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.32 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.32 |
| ▸ | TUBB | P07437 | 1/20 | 0.32 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.32 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6718657 | 0.83 | NR4A2 (0.41) | HCAR2ABCG2MAPTCDK8DHODH | |
| SCHEMBL15346406 | 0.82 | HCAR2 (0.46) | HCAR2ABCG2KDM4EMAPTXPO1 | |
| SCHEMBL6713591 | 0.73 | HCAR2 (0.40) | HCAR2ABCG2KDM4EPARP1DHODH | |
| SCHEMBL6711937 | 0.70 | HCAR2 (0.41) | HCAR2ABCG2XPO1LMNAKIF11 | |
| SCHEMBL15203033 | 0.69 | KIF11 (0.35) | KDM4EMAPTBACE1KIF11 | |
| SCHEMBL15646458 | 0.69 | RORC (0.47) | KDM4EMAPTTUBB4ATUBBTUBA3C | |
| SCHEMBL15203044 | 0.66 | NOTUM (0.34) | — | |
| SCHEMBL23618593 | 0.66 | ALDH1A1 (0.43) | HCAR2ABCG2KDM4EMAPTCYP3A4 | |
| SCHEMBL24604916 | 0.66 | DHODH (0.41) | HCAR2ABCG2KDM4EMAPTCYP3A4 | |
| SCHEMBL359732 | 0.63 | NPC1 (0.63) | KDM4EMAPTDYRK1ACYP3A4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6825210-B2 | 5,10-DIHYDROBENZO(B)(1,8)NAPHTHYRIDINE COMPOUNDS, N-OXIDES; 3,7-DICHLORO-5-ISOPROPOXYMETHYL-5-TRIFLUOROMETHYL-5,10 -DIHYDROBENZO(B)(1,8)NAPHTHYRIDINE FOR EXAMPLE; COMBINATION THERAPY | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-11-30 | — | — | US | disclosed |
| US-20020177603-A1 | Tricyclic compounds useful as HIV reverse transcriptase inhibitors | BRISTOL-MYERS SQUIBB PHARMA COMPANY (FORMERLY DUPONT PHARMACEUTICALS COMPANY) | 2002-11-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020177603-A1 | Tricyclic compounds useful as HIV reverse transcriptase inhibitors | POLRMT, TYMP, POLM | HCAR2 3735/4885ABCG2 793/4885KDM4E 3147/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.