SCHEMBL6712224

SCHEMBL6712224

N#Cc1ccc(NC(=O)c2noc3ccc(N)cc23)c(-c2nnn[nH]2)c1

nearest known ligand 0.34

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 10/20 0.34
LRRK2 Q5S007 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6710001 0.93 HIF1A (0.34) HIF1ALRRK2
SCHEMBL6709290 0.89 GPR35 (0.34) HIF1ALRRK2
SCHEMBL6709888 0.88 HIF1A (0.47) HIF1A
SCHEMBL6711746 0.87 HIF1A (0.41) HIF1ALRRK2
SCHEMBL6711660 0.87 HIF1A (0.43) HIF1ALRRK2
SCHEMBL6708933 0.87 LRRK2 (0.38) HIF1ALRRK2
SCHEMBL6707747 0.86 HIF1A (0.35) HIF1A
SCHEMBL6708718 0.86 HIF1A (0.42) HIF1A
SCHEMBL6710262 0.86 HIF1A (0.42) HIF1A
SCHEMBL6710307 0.86 CSF1R (0.37) HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040142981-A1 Antibacterial benzoic acid derivatives PHARMACIA & UPJOHN COMPANY 2004-07-22 US disclosed
WO-2004018461-A2 ANTIBACTERIAL BENZOIC ACID DERIVATIVES PHARMACIA & UPJOHN COMPANY LLC (US) 2004-03-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040142981-A1 Antibacterial benzoic acid derivatives GABRD, PHB1, GABBR1 HIF1A 296/4885LRRK2 4612/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.